Publications: Steven Szczepanek

• 2023

• A Single-Administration Microneedle Skin Patch for Multi-Burst Release of Vaccine against SARS-CoV-2.
  Tran KTM, Gavitt TD, Le TT, Graichen A, Lin F, Liu Y, Tulman ER, Szczepanek SM, Nguyen TD
  Advanced materials technologies (2023) :2200905 PMC7349596 10.1002/admt.202200905

• 2022

• B cells oppose Mycoplasma pneumoniae vaccine enhanced disease and limit bacterial colonization of the lungs.
  Gavitt TD, Mara AB, Goodridge ML, Ozyck RG, Reinhardt E, Miller JM, Hunte M, Tulman ER, Frasca S, Silbart LK, Geary SJ, Szczepanek SM
  NPJ vaccines (2022) 7(1):130 PMC98411 10.1016/S0021-9258(19)69848-0
• Vaccination with Mycoplasma pneumoniae membrane lipoproteins induces IL-17A driven neutrophilia that mediates Vaccine-Enhanced Disease.
  Mara AB, Gavitt TD, Tulman ER, Miller JM, He W, Reinhardt EM, Ozyck RG, Goodridge ML, Silbart LK, Szczepanek SM, Geary SJ
  NPJ vaccines (2022) 7(1):86 PMC6202950 10.3389/fimmu.2018.02405

• 2021

• A GATA3 Targeting Nucleic Acid Nanocapsule for Gene Regulation in Asthma.
  Gavitt TD, Hartmann AK, Sawant SS, Mara AB, Szczepanek SM, Rouge JL
  ACS nano (2021) 15(7):11192-11201 PMC9200080 10.1021/acsnano.0c07781
• Lipid moieties of Mycoplasma pneumoniae lipoproteins are the causative factor of vaccine-enhanced disease.
  Mara AB, Gavitt TD, Tulman ER, Geary SJ, Szczepanek SM
  NPJ vaccines (2021) 5(1):31 10.1093/nar/gky1106

• 2020

• Transdermal microneedles for the programmable burst release of multiple vaccine payloads.
  Tran KTM, Gavitt TD, Farrell NJ, Curry EJ, Mara AB, Patel A, Brown L, Kilpatrick S, Piotrowska R, Mishra N, Szczepanek SM, Nguyen TD
  Nature biomedical engineering (2020) 5(9):998-1007 10.1128/cdli.4.4.415-422.1997
• Lipid moieties of lipoproteins are the causative factor of vaccine-enhanced disease.
  Mara AB, Gavitt TD, Tulman ER, Geary SJ, Szczepanek SM
  NPJ vaccines (2020) 5(1):31 PMC7142147 10.1038/s41541-020-0181-x

• 2019

• Transcriptional and Pathological Host Responses to Coinfection with Virulent or Attenuated Mycoplasma gallisepticum and Low-Pathogenic Avian Influenza A Virus in Chickens.
  Canter JA, Tulman ER, Beaudet J, Lee DH, May M, Szczepanek SM, Geary SJ
  Infection and immunity (2019) 88(1): PMC6921668 10.1128/IAI.00607-19
• The VP1 G-H loop hypervariable epitope contributes to protective immunity against Foot and Mouth Disease Virus in swine.
  Fernandez-Sainz I, Gavitt TD, Koster M, Ramirez-Medina E, Rodriguez YY, Wu P, Silbart LK, de Los Santos T, Szczepanek SM
  Vaccine (2019) 37(26):3435-3442 10.1016/j.vaccine.2019.05.019
• House Dust Mite-Induced Allergic Lung Inflammation Is Not Exacerbated in Sickle Cell Disease Mice.
  Jiang C, Gavitt TD, Szczepanek SM
  International archives of allergy and immunology (2019) 179(3):192-200 10.1159/000499043
• Snake Fungal Disease in Colubridae Snakes in Connecticut, USA in 2015 and 2017.
  Licitra D, Quinn DP, Reeder JE, Gavitt T, Dickson J, Hess B, Mangold BJ, Tuttle AD, Rosas-Rosas A, Frasca S, Szczepanek SM
  Journal of wildlife diseases (2019) 55(3):658-662 10.7589/2018-04-100

• 2018

• Influenza Vaccination Protects Against Pandemic H1N1 Infection in Sickle Cell Disease Mice.
  Roberts S, Metzger DW, Szczepanek SM
  Viral Immunol. (2018) 31(6):470-471 10.1089/vim.2018.0024

• 2017

• Transcriptional Profiling of the Chicken Tracheal Response to Virulent Mycoplasma gallisepticum Strain R.
  Beaudet J, Tulman ER, Pflaum K, Liao X, Kutish GF, Szczepanek SM, Silbart LK, Geary SJ
  Infect. Immun. (2017) 85(10): (PMC5607433) 10.1128/IAI.00343-17
• Peritoneal B-1b and B-2 B-cells confer long-term protection from pneumococcal serotype 3 infection after vaccination with Prevnar-13 and are defective in sickle cell disease mice.
  Cotte C, Szczepanek SM
  Vaccine (2017) 35(28):3520-3522 10.1016/j.vaccine.2017.05.039

• 2016

• Poor Long-Term Efficacy of Prevnar-13 in Sickle Cell Disease Mice Is Associated with an Inability to Sustain Pneumococcal-Specific Antibody Titers.
  Szczepanek SM, Roberts S, Rogers K, Cotte C, Adami AJ, Bracken SJ, Salmon S, Secor ER, Thrall RS, Andemariam B, Metzger DW
  PLoS ONE (2016) 11(2):e0149261 (PMC4766082) 10.1371/journal.pone.0149261

• 2015

• Long-Term Exposure to House Dust Mite Leads to the Suppression of Allergic Airway Disease Despite Persistent Lung Inflammation.
  Bracken SJ, Adami AJ, Szczepanek SM, Ehsan M, Natarajan P, Guernsey LA, Shahriari N, Rafti E, Matson AP, Schramm CM, Thrall RS
  Int. Arch. Allergy Immunol. (2015) 166(4):243-58 (PMC4485530) 10.1159/000381058

• 2014

• Hydrogen peroxide production from glycerol metabolism is dispensable for virulence of Mycoplasma gallisepticum in the tracheas of chickens.
  Szczepanek SM, Boccaccio M, Pflaum K, Liao X, Geary SJ
  Infect. Immun. (2014) 82(12):4915-20 (PMC4249280) 10.1128/IAI.02208-14
• Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells.
  Secor ER, Szczepanek SM, Castater CA, Adami AJ, Matson AP, Rafti ET, Guernsey L, Natarajan P, McNamara JT, Schramm CM, Thrall RS, Silbart LK
  Evid Based Complement Alternat Med (2014) 2013:702196 (PMC3870104) 10.1155/2013/702196

• 2013

• Semi-automated curation of metabolic models via flux balance analysis: a case study with Mycoplasma gallisepticum.
  Bautista EJ, Zinski J, Szczepanek SM, Johnson EL, Tulman ER, Ching WM, Geary SJ, Srivastava R
  PLoS Comput. Biol. (2013) 9(9):e1003208 (PMC3764002) 10.1371/journal.pcbi.1003208
• Transgenic sickle cell disease mice have high mortality and dysregulated immune responses after vaccination.
  Szczepanek SM, Secor ER, Bracken SJ, Guernsey L, Rafti E, Matson A, Thrall RS, Andemariam B
  Pediatr. Res. (2013) 74(2):141-7 (PMC4487511) 10.1038/pr.2013.85

• 2012

• LC-MS/MS Identification of a Bromelain Peptide Biomarker from Ananas comosus Merr.
  Secor ER, Szczepanek SM, Singh A, Guernsey L, Natarajan P, Rezaul K, Han DK, Thrall RS, Silbart LK
  Evid Based Complement Alternat Med (2012) 2012:548486 (PMC3467939) 10.1155/2012/548486
• Splenic morphological changes are accompanied by altered baseline immunity in a mouse model of sickle-cell disease.
  Szczepanek SM, McNamara JT, Secor ER, Natarajan P, Guernsey LA, Miller LA, Ballesteros E, Jellison E, Thrall RS, Andemariam B
  Am. J. Pathol. (2012) 181(5):1725-34 (PMC3483810) 10.1016/j.ajpath.2012.07.034
• Extensive variation in surface lipoprotein gene content and genomic changes associated with virulence during evolution of a novel North American house finch epizootic strain of Mycoplasma gallisepticum.
  Tulman ER, Liao X, Szczepanek SM, Ley DH, Kutish GF, Geary SJ
  Microbiology (Reading, Engl.) (2012) 158(Pt 8):2073-88 10.1099/mic.0.058560-0
• Xenoepitope substitution avoids deceptive imprinting and broadens the immune response to foot-and-mouth disease virus.
  Szczepanek SM, Barrette RW, Rood D, Alejo D, Silbart LK
  Clin. Vaccine Immunol. (2012) 19(4):461-7 (PMC3318270) 10.1128/CVI.00035-12
• Bacterial Toxin Fusion Proteins Elicit Mucosal Immunity against a Foot-and-Mouth Disease Virus Antigen When Administered Intranasally to Guinea Pigs.
  Challa S, Szczepanek SM, Rood D, Barrette RW, Silbart LK
  Adv Virol (2012) 2011:713769 (PMC3265312) 10.1155/2011/713769
• Vaccination of BALB/c mice with an avirulent Mycoplasma pneumoniae P30 mutant results in disease exacerbation upon challenge with a virulent strain.
  Szczepanek SM, Majumder S, Sheppard ES, Liao X, Rood D, Tulman ER, Wyand S, Krause DC, Silbart LK, Geary SJ
  Infect. Immun. (2012) 80(3):1007-14 (PMC3294651) 10.1128/IAI.06078-11

• 2011

• Effects of sialidase knockout and complementation on virulence of Mycoplasma gallisepticum.
  May M, Szczepanek SM, Frasca S, Gates AE, Demcovitz DL, Moneypenny CG, Brown DR, Geary SJ
  Vet. Microbiol. (2011) 157(1-2):91-5 10.1016/j.vetmic.2011.12.004
• Use of inactivated Escherichia coli enterotoxins to enhance respiratory mucosal adjuvanticity during vaccination in swine.
  Barrette RW, Szczepanek SM, Rood D, Challa S, Avery N, Vajdy M, Kramer E, Rodriguez L, Silbart LK
  Clin. Vaccine Immunol. (2011) 18(11):1996-8 (PMC3209021) 10.1128/CVI.05273-11

• 2010

• Identification of lipoprotein MslA as a neoteric virulence factor of Mycoplasma gallisepticum.
  Szczepanek SM, Frasca S, Schumacher VL, Liao X, Padula M, Djordjevic SP, Geary SJ
  Infect. Immun. (2010) 78(8):3475-83 (PMC2916287) 10.1128/IAI.00154-10
• Comparative genomic analyses of attenuated strains of Mycoplasma gallisepticum.
  Szczepanek SM, Tulman ER, Gorton TS, Liao X, Lu Z, Zinski J, Aziz F, Frasca S, Kutish GF, Geary SJ
  Infect. Immun. (2010) 78(4):1760-71 (PMC2849401) 10.1128/IAI.01172-09

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