Publications: Michael Lynes
2024
- Extracellular metallothionein as a therapeutic target in the early progression of type 1 diabetes.
Melchiorre CK, Lynes MD, Bhandari S, Su SC, Potts CM, Thees AV, Norris CE, Liaw L, Tseng YH, Lynes MA
Cell stress & chaperones (2024) 29(2):312-325 PMC3615023 10.1371/JOURNAL.PONE.0060229 2023
- Development of a biomarker signature using grating-coupled fluorescence plasmonic microarray for diagnosis of MIS-C.
Maltz-Matyschsyk M, Melchiorre CK, Herbst KW, Hogan AH, Dibble K, O'Sullivan B, Graf J, Jadhav A, Lawrence DA, Lee WT, Carson KJ, Radolf JD, Salazar JC, Lynes MA,
Frontiers in bioengineering and biotechnology (2023) 11:1066391 PMC6349798 10.1007/s00467-018-4087-z 2021
- PmtA Regulates Pyocyanin Expression and Biofilm Formation in .
Thees AV, Pietrosimone KM, Melchiorre CK, Marden JN, Graf J, Lynes MA, Maltz-Matyschsyk M
Frontiers in microbiology (2021) 12:789765 PMC8636135 10.3389/fmicb.2021.789765 - Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen-induced liver injury.
Devisscher L, Van Campenhout S, Lefere S, Raevens S, Tilleman L, Van Nieuwerburgh F, Van Eeckhoutte HP, Hoorens A, Lynes MA, Geerts A, Laukens D, Van Vlierberghe H
Journal of leukocyte biology (2021) 111(1):123-133 10.1002/JLB.3A0820-527R 2020
- Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion.
Riedelberger M, Penninger P, Tscherner M, Hadriga B, Brunnhofer C, Jenull S, Stoiber A, Bourgeois C, Petryshyn A, Glaser W, Limbeck A, Lynes MA, Schabbauer G, Weiss G, Kuchler K
iScience (2020) 23(5):101121 PMC7232100 10.1016/j.isci.2020.101121 2018
- Metallothionein: A Novel Therapeutic Target for Treatment of Inflammatory Bowel Disease.
Dostie KE, Thees AV, Lynes MA
Curr. Pharm. Des. (2018) 24(27):3155-3161 10.2174/1381612824666180717110236 2017
- Detection and Manipulation of the Stress Response Protein Metallothionein.
Bhandari S, Melchiorre C, Dostie K, Laukens D, Devisscher L, Louwrier A, Thees A, Lynes MA
Curr Protoc Toxicol (2017) 71:17.19.1-17.19.28 2016
- Biomonitoring in the Era of the Exposome.
Dennis KK, Marder E, Balshaw DM, Cui Y, Lynes MA, Patti GJ, Rappaport SM, Shaughnessy DT, Vrijheid M, Barr DB
Environ. Health Perspect. (2016) 125(4):502-510 (PMC5381997) - Metallothionein regulates intracellular zinc signaling during CD4(+) T cell activation.
Rice JM, Zweifach A, Lynes MA
BMC Immunol. (2016) 17(1):13 (PMC4890327) 2015
- Metallothionein differentially affects the host response to Listeria infection both with and without an additional stress from cold-restraint.
Emeny RT, Kasten-Jolly J, Mondal T, Lynes MA, Lawrence DA
Cell Stress Chaperones (2015) 20(6):1013-22 (PMC4595426) 2014
- Metallothionein and stress combine to affect multiple organ systems.
Lynes MA, Hidalgo J, Manso Y, Devisscher L, Laukens D, Lawrence DA
Cell Stress Chaperones (2014) 19(5):605-11 (PMC4147071) - In vitro assays of chemotaxis as a window into mechanisms of toxicant-induced immunomodulation.
Pietrosimone KM, Bhandari S, Lemieux MG, Knecht DA, Lynes MA
Curr Protoc Toxicol (2014) 58:Unit 18.17. - Sensitivity enhancement of a grating-based surface plasmon-coupled emission (SPCE) bionsor chip using gold thickness.
Yuk JS, Guignon EF, Lynes MA
Chem Phys Lett (2014) 591:5-9 (PMC3909983) - Role of metallothioneins as danger signals in the pathogenesis of colitis.
Devisscher L, Hindryckx P, Lynes MA, Waeytens A, Cuvelier C, De Vos F, Vanhove C, Vos MD, Laukens D
J. Pathol. (2014) 233(1):89-100 2013
- Cloning and characterization of a hybridoma secreting a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-specific monoclonal antibody and recombinant F(ab).
Wanczyk H, Barker T, Rood D, Zapata DI, Howell AR, Richardson SK, Zinckgraf J, Marusov GP, Lynes MA, Silbart LK
Toxins (Basel) (2013) 5(3):568-89 (PMC3705279) - Highly sensitive grating coupler-based surface plasmon-coupled emission (SPCE) biosensor for immunoassay.
Yuk JS, Guignon EF, Lynes MA
Analyst (2013) 138(9):2576-82 2012
- Mining the salivary proteome with grating-coupled surface plasmon resonance imaging and surface plasmon coupled emission microarrays.
Molony RD, Rice JM, Yuk JS, Shetty V, Dey D, Lawrence DA, Lynes MA
Curr Protoc Toxicol (2012) Chapter 18:Unit 18.16.1-19 (PMC3461276) - Analysis of immunoarrays using a gold grating-based dual mode surface plasmon-coupled emission (SPCE) sensor chip.
Yuk JS, Gibson GN, Rice JM, Guignon EF, Lynes MA
Analyst (2012) 137(11):2574-81 - Measurement of cellular chemotaxis with ECIS/Taxis.
Pietrosimone KM, Yin X, Knecht DA, Lynes MA
J Vis Exp (2012) (62): (PMC3460541) 2011
- Antigen-specific T cell phenotyping microarrays using grating coupled surface plasmon resonance imaging and surface plasmon coupled emission.
Rice JM, Stern LJ, Guignon EF, Lawrence DA, Lynes MA
Biosens Bioelectron (2011) 31(1):264-9 (PMC3249003) - A microarray biosensor for multiplexed detection of microbes using grating-coupled surface plasmon resonance imaging.
Marusov G, Sweatt A, Pietrosimone K, Benson D, Geary SJ, Silbart LK, Challa S, Lagoy J, Lawrence DA, Lynes MA
Environ. Sci. Technol. (2011) 46(1):348-59 (PMC3312245) 2009
- Manipulations of metallothionein gene dose accelerate the response to Listeria monocytogenes.
Emeny RT, Marusov G, Lawrence DA, Pederson-Lane J, Yin X, Lynes MA
Chem. Biol. Interact. (2009) 181(2):243-53 2007
- Heavy metal ions in normal physiology, toxic stress, and cytoprotection.
Lynes MA, Kang YJ, Sensi SL, Perdrizet GA, Hightower LE
Ann. N. Y. Acad. Sci. (2007) 1113:159-72 - Automated real-time measurements of leukocyte chemotaxis.
Hadjout N, Yin X, Knecht DA, Lynes MA
J. Immunol. Methods (2007) 320(1-2):70-80 (PMC1934897) 2006
- The physiological roles of extracellular metallothionein.
Lynes MA, Zaffuto K, Unfricht DW, Marusov G, Samson JS, Yin X
Exp. Biol. Med. (Maywood) (2006) 231(9):1548-54 - Metallothionein and anti-metallothionein, complementary elements of cadmium-induced renal disease.
Lynes MA, Yin X
Toxicol. Sci. (2006) 91(1):1-3 - Cytometry on a chip: cellular phenotypic and functional analysis using grating-coupled surface plasmon resonance.
Jin GB, Unfricht DW, Fernandez SM, Lynes MA
Biosens Bioelectron (2006) 22(2):200-6 2005
- Grating-coupled surface plasmon resonance: a cell and protein microarray platform.
Unfricht DW, Colpitts SL, Fernandez SM, Lynes MA
Proteomics (2005) 5(17):4432-42 - Metallothionein mediates leukocyte chemotaxis.
Yin X, Knecht DA, Lynes MA
BMC Immunol. (2005) 6:21 (PMC1262721) - Gene expression influences on metal immunomodulation.
Lynes MA, Fontenot AP, Lawrence DA, Rosenspire AJ, Pollard KM
Toxicol. Appl. Pharmacol. (2005) 210(1-2):9-16 - Solid-phase immunoassays.
Lynes MA
Curr Protoc Toxicol (2005) Chapter 18:Unit18.7 2003
- Shrinking the biologic world--nanobiotechnologies for toxicology.
Zieziulewicz TJ, Unfricht DW, Hadjout N, Lynes MA, Lawrence DA
Toxicol. Sci. (2003) 74(2):235-44 - Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient "viable motheaten" mice.
Lyons BL, Lynes MA, Burzenski L, Joliat MJ, Hadjout N, Shultz LD
Exp. Hematol. (2003) 31(3):234-43 2002
- Establishment and characterization of a new osteogenic cell line (MOS-J) from a spontaneous C57BL/6J mouse osteosarcoma.
Joliat MJ, Umeda S, Lyons BL, Lynes MA, Shultz LD
In Vivo (2002) 16(4):223-8 - Metallothionein suppresses collagen-induced arthritis via induction of TGF-beta and down-regulation of proinflammatory mediators.
Youn J, Hwang SH, Ryoo ZY, Lynes MA, Paik DJ, Chung HS, Kim HY
Clin. Exp. Immunol. (2002) 129(2):232-9 (PMC1906452) - Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice.
Joliat MJ, Lang PA, Lyons BL, Burzenski L, Lynes MA, Yi T, Sundberg JP, Shultz LD
J. Autoimmun. (2002) 18(2):105-17 2001
- Automated real-time measurement of chemotactic cell motility.
Hadjout N, Laevsky G, Knecht DA, Lynes MA
BioTechniques (2001) 31(5):1130-8 - Effects of hemizygous CD45 expression in the autoimmune Fasl(gld/gld) syndrome.
Brooks WP, Lynes MA
Cell. Immunol. (2001) 212(1):24-34 - In vivo manipulation of endogenous metallothionein with a monoclonal antibody enhances a T-dependent humoral immune response.
Canpolat E, Lynes MA
Toxicol. Sci. (2001) 62(1):61-70