Publications: Ken Campellone
2024
- WHAMM functions in kidney reabsorption and polymerizes actin to promote autophagosomal membrane closure and cargo sequestration.
Coulter AM, Cortés V, Theodore CJ, Cianciolo RE, Korstanje R, Campellone KG
Molecular biology of the cell (2024) :mbcE24010025 10.1091/mbc.E24-01-0025 - Autophagosome turnover requires Arp2/3 complex-mediated maintenance of lysosomal integrity.
Theodore CJ, Wagner LH, Campellone KG
bioRxiv : the preprint server for biology (2024) : PMC10881176 10.1101/2024.03.12.584718 - WHAMM functions in kidney reabsorption and polymerizes actin to promote autophagosomal membrane closure and cargo sequestration.
Coulter AM, Cortés V, Theodore CJ, Cianciolo RE, Korstanje R, Campellone KG
bioRxiv : the preprint server for biology (2024) : PMC2763628 10.1101/2024.01.22.576497 2023
- F-actin-rich territories coordinate apoptosome assembly and caspase activation during DNA damage-induced intrinsic apoptosis.
King VL, Campellone KG
Molecular biology of the cell (2023) 34(5):ar41 PMC2763628 10.1091/mbc.E22-04-0119 - Branching out in different directions: Emerging cellular functions for the Arp2/3 complex and WASP-family actin nucleation factors.
Campellone KG, Lebek NM, King VL
European journal of cell biology (2023) 102(2):151301 PMC3290644 10.1091/mbc.E11-12-0992 - Genomic instability caused by Arp2/3 complex inactivation results in micronucleus biogenesis and cellular senescence.
Haarer EL, Theodore CJ, Guo S, Frier RB, Campellone KG
PLoS genetics (2023) 19(1):e1010045 PMC3855844 10.1038/nmeth.2019 2021
- The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis.
King VL, Leclair NK, Coulter AM, Campellone KG
PLoS genetics (2021) 17(4):e1009512 PMC8084344 10.1371/journal.pgen.1009512 2020
- Adding SNX to the mix: SNX9 drives filopodia biogenesis.
Lebek NM, Campellone KG
The Journal of cell biology (2020) 219(4): PMC7147100 10.1083/jcb.202002086 - WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motility.
Kabrawala S, Zimmer MD, Campellone KG
PLoS genetics (2020) 16(3):e1008694 PMC7112243 10.1371/journal.pgen.1008694 2018
- Enteropathogenic E. coli relies on collaboration between the formin mDia1 and the Arp2/3 complex for actin pedestal biogenesis and maintenance.
Velle KB, Campellone KG
PLoS Pathog. (2018) 14(12):e1007485 (PMC6310289) 10.1371/journal.ppat.1007485 - Actin dynamics and function.
Gupton SL, Campellone KG
Mol. Biol. Cell (2018) 29(6):696-697 (PMC6003229) 10.1091/mbc.E18-01-0010 2017
- Extracellular motility and cell-to-cell transmission of enterohemorrhagic E. coli is driven by EspFU-mediated actin assembly.
Velle KB, Campellone KG
PLoS Pathog. (2017) 13(8):e1006501 (PMC5557606) 10.1371/journal.ppat.1006501 - An Amish founder mutation disrupts a PI(3)P-WHAMM-Arp2/3 complex-driven autophagosomal remodeling pathway.
Mathiowetz AJ, Baple E, Russo AJ, Coulter AM, Carrano E, Brown JD, Jinks RN, Crosby AH, Campellone KG
Mol. Biol. Cell (2017) 28(19):2492-2507 (PMC5597322) 10.1091/mbc.E17-01-0022 2016
- Rab1 recruits WHAMM during membrane remodeling but limits actin nucleation.
Russo AJ, Mathiowetz AJ, Hong S, Welch MD, Campellone KG
Mol. Biol. Cell (2016) 27(6):967-78 (PMC4791140) 10.1091/mbc.E15-07-0508 2015
- Integration of linear and dendritic actin nucleation in Nck-induced actin comets.
Borinskaya S, Velle KB, Campellone KG, Talman A, Alvarez D, Agaisse H, Wu YI, Loew LM, Mayer BJ
Mol. Biol. Cell (2015) 27(2):247-59 (PMC4713129) 10.1091/mbc.E14-11-1555 - Recessive nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum is caused by homozygous protein-truncating mutations of WDR73.
Jinks RN, Puffenberger EG, Baple E, Harding B, Crino P, Fogo AB, Wenger O, Xin B, Koehler AE, McGlincy MH, Provencher MM, Smith JD, Tran L, Al Turki S, Chioza BA, Cross H, Harlalka GV, Hurles ME, Maroofian R, Heaps AD, Morton MC, Stempak L, Hildebrandt F, Sadowski CE, Zaritsky J, Campellone K, Morton DH, Wang H, Crosby A, Strauss KA
Brain (2015) 138(Pt 8):2173-90 (PMC4511861) 10.1093/brain/awv153 2012
- Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling.
Shen QT, Hsiue PP, Sindelar CV, Welch MD, Campellone KG, Wang HW
J. Cell Biol. (2012) 199(1):111-24 (PMC3461504) 10.1083/jcb.201204010 - Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli.
Campellone KG, Siripala AD, Leong JM, Welch MD
J. Biol. Chem. (2012) 287(24):20613-24 (PMC3370245) 10.1074/jbc.M112.363473 2010
- Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.
Huang J, Birmingham CL, Shahnazari S, Shiu J, Zheng YT, Smith AC, Campellone KG, Heo WD, Gruenheid S, Meyer T, Welch MD, Ktistakis NT, Kim PK, Klionsky DJ, Brumell JH
Autophagy (2010) 7(1):17-26 (PMC3039730) 10.4161/auto.7.1.13840 - WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond.
Rottner K, Hänisch J, Campellone KG
Trends Cell Biol. (2010) 20(11):650-61 10.1016/j.tcb.2010.08.014 - Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation.
Vingadassalom D, Campellone KG, Brady MJ, Skehan B, Battle SE, Robbins D, Kapoor A, Hecht G, Snapper SB, Leong JM
PLoS Pathog. (2010) 6(8):e1001056 (PMC2924363) 10.1371/journal.ppat.1001056 - Cytoskeleton-modulating effectors of enteropathogenic and enterohaemorrhagic Escherichia coli: Tir, EspFU and actin pedestal assembly.
Campellone KG
FEBS J. (2010) 277(11):2390-402 10.1111/j.1742-4658.2010.07653.x - A nucleator arms race: cellular control of actin assembly.
Campellone KG, Welch MD
Nat. Rev. Mol. Cell Biol. (2010) 11(4):237-51 (PMC2929822) 10.1038/nrm2867 - Phosphoinositides influence pathogen surfing: EPEC rights the SHIP.
Campellone KG
Cell Host Microbe (2010) 7(1):1-2 10.1016/j.chom.2009.12.006 2008
- Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly.
Campellone KG, Cheng HC, Robbins D, Siripala AD, McGhie EJ, Hayward RD, Welch MD, Rosen MK, Koronakis V, Leong JM
PLoS Pathog. (2008) 4(10):e1000191 (PMC2567903) 10.1371/journal.ppat.1000191 - Interaction of enterohemorrhagic Escherichia coli (EHEC) with mammalian cells: cell adhesion, type III secretion, and actin pedestal formation.
Savage PJ, Campellone KG, Leong JM
Curr Protoc Microbiol (2008) Chapter 5:Unit 5A.1 10.1002/9780471729259.mc05a01s05 - Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U).
Cheng HC, Skehan BM, Campellone KG, Leong JM, Rosen MK
Nature (2008) 454(7207):1009-13 (PMC2719906) 10.1038/nature07160 - WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport.
Campellone KG, Webb NJ, Znameroski EA, Welch MD
Cell (2008) 134(1):148-61 (PMC2556884) 10.1016/j.cell.2008.05.032 2007
- EspFU, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7.
Ritchie JM, Brady MJ, Riley KN, Ho TD, Campellone KG, Herman IM, Donohue-Rolfe A, Tzipori S, Waldor MK, Leong JM
Cell. Microbiol. (2007) 10(4):836-47 (PMC2504705) 10.1111/j.1462-5822.2007.01087.x - Enterohaemorrhagic and enteropathogenic Escherichia coli Tir proteins trigger a common Nck-independent actin assembly pathway.
Brady MJ, Campellone KG, Ghildiyal M, Leong JM
Cell. Microbiol. (2007) 9(9):2242-53 10.1111/j.1462-5822.2007.00954.x - Increased adherence and actin pedestal formation by dam-deficient enterohaemorrhagic Escherichia coli O157:H7.
Campellone KG, Roe AJ, Løbner-Olesen A, Murphy KC, Magoun L, Brady MJ, Donohue-Rolfe A, Tzipori S, Gally DL, Leong JM, Marinus MG
Mol. Microbiol. (2007) 63(5):1468-81 10.1111/j.1365-2958.2007.05602.x 2006
- Enterohaemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF-mediated actin assembly and harbours N-terminal sequences that influence pedestal length.
Campellone KG, Brady MJ, Alamares JG, Rowe DC, Skehan BM, Tipper DJ, Leong JM
Cell. Microbiol. (2006) 8(9):1488-503 10.1111/j.1462-5822.2006.00728.x - Exploiting pathogenic Escherichia coli to model transmembrane receptor signalling.
Hayward RD, Leong JM, Koronakis V, Campellone KG
Nat. Rev. Microbiol. (2006) 4(5):358-70 10.1038/nrmicro1391 2005
- Nck-independent actin assembly is mediated by two phosphorylated tyrosines within enteropathogenic Escherichia coli Tir.
Campellone KG, Leong JM
Mol. Microbiol. (2005) 56(2):416-32 http:/10.1111/j.1365-2958.2005.04558.x 2004
- EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly.
Campellone KG, Robbins D, Leong JM
Dev. Cell (2004) 7(2):217-28 10.1016/j.devcel.2004.07.004 - Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly.
Campellone KG, Rankin S, Pawson T, Kirschner MW, Tipper DJ, Leong JM
J. Cell Biol. (2004) 164(3):407-16 (PMC2172230) 10.1083/jcb.200306032 2003
- Lambda Red-mediated recombinogenic engineering of enterohemorrhagic and enteropathogenic E. coli.
Murphy KC, Campellone KG
BMC Mol. Biol. (2003) 4:11 (PMC317293) 10.1186/1471-2199-4-11 - Tails of two Tirs: actin pedestal formation by enteropathogenic E. coli and enterohemorrhagic E. coli O157:H7.
Campellone KG, Leong JM
Curr. Opin. Microbiol. (2003) 6(1):82-90 2002
- Point mutants of EHEC intimin that diminish Tir recognition and actin pedestal formation highlight a putative Tir binding pocket.
Liu H, Radhakrishnan P, Magoun L, Prabu M, Campellone KG, Savage P, He F, Schiffer CA, Leong JM
Mol. Microbiol. (2002) 45(6):1557-73 - A tyrosine-phosphorylated 12-amino-acid sequence of enteropathogenic Escherichia coli Tir binds the host adaptor protein Nck and is required for Nck localization to actin pedestals.
Campellone KG, Giese A, Tipper DJ, Leong JM
Mol. Microbiol. (2002) 43(5):1227-41 2000
- PCR-mediated gene replacement in Escherichia coli.
Murphy KC, Campellone KG, Poteete AR
Gene (2000) 246(1-2):321-30 0
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