Publications: Justin D. Radolf

• 2024

• Clinical presentation of early syphilis and genomic sequences of Treponema pallidum strains in patient specimens and isolates obtained by rabbit inoculation.
  Yang L, Zhang X, Chen W, Seña AC, Zheng H, Jiang Y, Zhao P, Chen R, Wang L, Ke W, Salazar JC, Parr JB, Tucker JD, Hawley KL, Caimano MJ, Hennelly CM, Aghakanian F, Bettin EB, Zhang F, Chen JS, Moody MA, Radolf JD, Yang B
  The Journal of infectious diseases (2024) : 10.1093/infdis/jiae322

• 2023

• Early syphilis in Guangzhou, China: presentation, molecular detection of , and genomic sequences in clinical specimens and isolates obtained by rabbit infectivity testing.
  Yang L, Zhang X, Chen W, Seña AC, Zheng H, Jiang Y, Zhao P, Chen R, Wang L, Ke W, Salazar JC, Parr JB, Tucker JD, Hawley KL, Caimano MJ, Hennelly CM, Aghakanian F, Zhang F, Chen JS, Moody MA, Radolf JD, Yang B
  medRxiv : the preprint server for health sciences (2023) : PMC10614984 10.1101/2023.10.17.23297169
• Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of BamA (TP0326).
  Ferguson MR, Delgado KN, McBride S, Orbe IC, La Vake CJ, Caimano MJ, Mendez Q, Moraes TF, Schryvers AB, Moody MA, Radolf JD, Weiner MP, Hawley KL
  Frontiers in immunology (2023) 14:1222267 PMC7709521 10.1128/MMBR.00078-20
• Clinical and genomic diversity of A global, multi-center study of early syphilis to inform vaccine research.
  Seña AC, Matoga MM, Yang L, Lopez-Medina E, Aghakanian F, Chen JS, Bettin EB, Caimano MJ, Chen W, Garcia-Luna JA, Hennelly CM, Jiang Y, Juliano JJ, Pospíšilová P, Ramirez L, Šmajs D, Tucker JD, Cely FV, Zheng H, Hoffman IF, Yang B, Moody MA, Hawley KL, Salazar JC, Radolf JD, Parr JB
  medRxiv : the preprint server for health sciences (2023) : PMC10402240 10.1101/2023.07.19.23291250
• Editorial: Syphilis infection: clinical, epidemiology, basic science, and behavioral research.
  Zhou P, Ye M, Tucker JD, Zhang L, Radolf JD
  Frontiers in immunology (2023) 14:1182069 PMC10117985 10.3389/fimmu.2023.1182069
• Development of a biomarker signature using grating-coupled fluorescence plasmonic microarray for diagnosis of MIS-C.
  Maltz-Matyschsyk M, Melchiorre CK, Herbst KW, Hogan AH, Dibble K, O'Sullivan B, Graf J, Jadhav A, Lawrence DA, Lee WT, Carson KJ, Radolf JD, Salazar JC, Lynes MA,
  Frontiers in bioengineering and biotechnology (2023) 11:1066391 PMC6349798 10.1007/s00467-018-4087-z
• BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammals.
  Grassmann AA, Tokarz R, Golino C, McLain MA, Groshong AM, Radolf JD, Caimano MJ
  The Journal of clinical investigation (2023) 133(5): PMC4302049 10.1186/s13059-014-0550-8

• 2022

• High-throughput nanopore sequencing of tandem repeat genes and reveals clade-specific patterns and recapitulates global whole genome phylogeny.
  Lieberman NAP, Armstrong TD, Chung B, Pfalmer D, Hennelly CM, Haynes A, Romeis E, Wang QQ, Zhang RL, Kou CX, Ciccarese G, Conte ID, Cusini M, Drago F, Nakayama SI, Lee K, Ohnishi M, Konda KA, Vargas SK, Eguiluz M, Caceres CF, Klausner JD, Mitja O, Rompalo A, Mulcahy F, Hook EW, Hoffman IF, Matoga MM, Zheng H, Yang B, Lopez-Medina E, Ramirez LG, Radolf JD, Hawley KL, Salazar JC, Lukehart SA, Seña AC, Parr JB, Giacani L, Greninger AL
  Frontiers in microbiology (2022) 13:1007056 PMC3630124 10.1371/journal.pntd.0002172
• A suite of PCR-LwCas13a assays for detection and genotyping of Treponema pallidum in clinical samples.
  Chen W, Luo H, Zeng L, Pan Y, Parr JB, Jiang Y, Cunningham CH, Hawley KL, Radolf JD, Ke W, Ou J, Yang J, Yang B, Zheng H
  Nature communications (2022) 13(1):4671 PMC6956564 10.1038/s41596-019-0210-2
• Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity.
  Ledala N, Malik M, Rezaul K, Paveglio S, Provatas A, Kiel A, Caimano M, Zhou Y, Lindgren J, Krasulova K, Illes P, Dvořák Z, Kortagere S, Kienesberger S, Cosic A, Pöltl L, Zechner EL, Ghosh S, Mani S, Radolf JD, Matson AP
  mBio (2022) 13(1):e0375221 PMC7136958 10.1038/nature07935

• 2021

• PlzA is a bifunctional c-di-GMP biosensor that promotes tick and mammalian host-adaptation of Borrelia burgdorferi.
  Groshong AM, Grassmann AA, Luthra A, McLain MA, Provatas AA, Radolf JD, Caimano MJ
  PLoS pathogens (2021) 17(7):e1009725 PMC8323883 10.1371/journal.ppat.1009725
• Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation.
  Benjamin SJ, Hawley KL, Vera-Licona P, La Vake CJ, Cervantes JL, Ruan Y, Radolf JD, Salazar JC
  BMC immunology (2021) 22(1):32 PMC8127205 10.1186/s12865-021-00418-8
• Structural modeling of the OMPeome: a roadmap for deconvolution of syphilis pathogenesis and development of a syphilis vaccine.
  Hawley KL, Montezuma-Rusca JM, Delgado KN, Singh N, Uversky VN, Caimano MJ, Radolf JD, Luthra A
  Journal of bacteriology (2021) : 10.1128/JB.00082-21
• Host-specific functional compartmentalization within the oligopeptide transporter during the Borrelia burgdorferi enzootic cycle.
  Groshong AM, McLain MA, Radolf JD
  PLoS pathogens (2021) 17(1):e1009180 PMC7822543 10.1371/journal.ppat.1009180

• 2020

• Lyme Disease in Humans.
  Radolf JD, Strle K, Lemieux JE, Strle F
  Current issues in molecular biology (2020) 42:333-384 PMC7946767 10.21775/cimb.042.333
• Outcomes From Re-Treatment and Cerebrospinal Fluid Analyses in Patients With Syphilis Who Had Serological Nonresponse or Lack of Seroreversion After Initial Therapy.
  Zhang X, Shahum A, Yang LG, Xue Y, Wang L, Yang B, Zheng H, Chen JS, Radolf JD, Seña AC
  Sexually transmitted diseases (2020) 48(6):443-450 PMC8058108 10.1097/OLQ.0000000000001321
• Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis.
  Luthra A, Montezuma-Rusca JM, La Vake CJ, LeDoyt M, Delgado KN, Davenport TC, Fiel-Gan M, Caimano MJ, Radolf JD, Hawley KL
  PLoS pathogens (2020) 16(9):e1008871 PMC7521688 10.1371/journal.ppat.1008871
• Analysis of Treponema pallidum Strains From China Using Improved Methods for Whole-Genome Sequencing From Primary Syphilis Chancres.
  Chen W, Šmajs D, Hu Y, Ke W, Pospíšilová P, Hawley KL, Caimano MJ, Radolf JD, Sena A, Tucker JD, Yang B, Juliano JJ, Zheng H, Parr JB
  The Journal of infectious diseases (2020) 223(5):848-853 PMC8171795 10.1093/infdis/jiaa449

• 2019

• The RpoS Gatekeeper in : An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity.
  Caimano MJ, Groshong AM, Belperron A, Mao J, Hawley KL, Luthra A, Graham DE, Earnhart CG, Marconi RT, Bockenstedt LK, Blevins JS, Radolf JD
  Frontiers in microbiology (2019) 10:1923 PMC6719511 10.3389/fmicb.2019.01923

• 2018

• Sequence Variation of Rare Outer Membrane Protein β-Barrel Domains in Clinical Strains Provides Insights into the Evolution of subsp. , the Syphilis Spirochete.
  Kumar S, Caimano MJ, Anand A, Dey A, Hawley KL, LeDoyt ME, La Vake CJ, Cruz AR, Ramirez LG, Paštěková L, Bezsonova I, Šmajs D, Salazar JC, Radolf JD
  MBio (2018) 9(3): (PMC6016234) 10.1128/mBio.01006-18

• 2017

• Peptide Uptake Is Essential for Viability and Involves Structural and Regulatory Complexity of its Oligopeptide Transporter.
  Groshong AM, Dey A, Bezsonova I, Caimano MJ, Radolf JD
  MBio (2017) 8(6): (PMC5736914)
• IFNγ Enhances CD64-Potentiated Phagocytosis of Opsonized with Human Syphilitic Serum by Human Macrophages.
  Hawley KL, Cruz AR, Benjamin SJ, La Vake CJ, Cervantes JL, LeDoyt M, Ramirez LG, Mandich D, Fiel-Gan M, Caimano MJ, Radolf JD, Salazar JC
  Front Immunol (2017) 8:1227 (PMC5633599)
• The major outer sheath protein forms distinct conformers and multimeric complexes in the outer membrane and periplasm of Treponema denticola.
  Puthenveetil R, Kumar S, Caimano MJ, Dey A, Anand A, Vinogradova O, Radolf JD
  Sci Rep (2017) 7(1):13260 (PMC5643300)
• Syphilis.
  Peeling RW, Mabey D, Kamb ML, Chen XS, Radolf JD, Benzaken AS
  Nat Rev Dis Primers (2017) 3:17073 (PMC5809176)
• The Treponema pallidum Outer Membrane.
  Radolf JD, Kumar S
  Curr. Top. Microbiol. Immunol. (2017) 415:1-38 (PMC5924592) 10.1007/82_2017_44
• Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by , the Lyme Disease Spirochete.
  Grove AP, Liveris D, Iyer R, Petzke M, Rudman J, Caimano MJ, Radolf JD, Schwartz I
  MBio (2017) 8(4): (PMC5565969)

• 2016

• Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen.
  Radolf JD, Deka RK, Anand A, Šmajs D, Norgard MV, Yang XF
  Nat. Rev. Microbiol. (2016) 14(12):744-759 (PMC5106329)
• Consensus computational network analysis for identifying candidate outer membrane proteins from Borrelia spirochetes.
  Kenedy MR, Scott EJ, Shrestha B, Anand A, Iqbal H, Radolf JD, Dyer DW, Akins DR
  BMC Microbiol. (2016) 16(1):141 (PMC4939628)
• Genomic insights into the Ixodes scapularis tick vector of Lyme disease.
  Gulia-Nuss M, Nuss AB, Meyer JM, Sonenshine DE, Roe RM, Waterhouse RM, Sattelle DB, de la Fuente J, Ribeiro JM, Megy K, Thimmapuram J, Miller JR, Walenz BP, Koren S, Hostetler JB, Thiagarajan M, Joardar VS, Hannick LI, Bidwell S, Hammond MP, Young S, Zeng Q, Abrudan JL, Almeida FC, Ayllón N, Bhide K, Bissinger BW, Bonzon-Kulichenko E, Buckingham SD, Caffrey DR, Caimano MJ, Croset V, Driscoll T, Gilbert D, Gillespie JJ, Giraldo-Calderón GI, Grabowski JM, Jiang D, Khalil SMS, Kim D, Kocan KM, Koči J, Kuhn RJ, Kurtti TJ, Lees K, Lang EG, Kennedy RC, Kwon H, Perera R, Qi Y, Radolf JD, Sakamoto JM, Sánchez-Gracia A, Severo MS, Silverman N, Šimo L, Tojo M, Tornador C, Van Zee JP, Vázquez J, Vieira FG, Villar M, Wespiser AR, Yang Y, Zhu J, Arensburger P, Pietrantonio PV, Barker SC, Shao R, Zdobnov EM, Hauser F, Grimmelikhuijzen CJP, Park Y, Rozas J, Benton R, Pedra JHF, Nelson DR, Unger MF, Tubio JMC, Tu Z, Robertson HM, Shumway M, Sutton G, Wortman JR, Lawson D, Wikel SK, Nene VM, Fraser CM, Collins FH, Birren B, Nelson KE, Caler E, Hill CA
  Nat Commun (2016) 7:10507 (PMC4748124)

• 2015

• A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy.
  Seña AC, Zhang XH, Li T, Zheng HP, Yang B, Yang LG, Salazar JC, Cohen MS, Moody MA, Radolf JD, Tucker JD
  BMC Infect. Dis. (2015) 15:479 (PMC4625448)
• Treponema pallidum in Gel Microdroplets: A Method for Topological Analysis of BamA (TP0326) and Localization of Rare Outer Membrane Proteins.
  Luthra A, Anand A, Radolf JD
  Methods Mol. Biol. (2015) 1329:67-75
• Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: A system for sensing small molecules associated with tick feeding.
  Bauer WJ, Luthra A, Zhu G, Radolf JD, Malkowski MG, Caimano MJ
  J. Struct. Biol. (2015) 192(1):48-58 (PMC4605270)
• Cyclic di-GMP modulates gene expression in Lyme disease spirochetes at the tick-mammal interface to promote spirochete survival during the blood meal and tick-to-mammal transmission.
  Caimano MJ, Dunham-Ems S, Allard AM, Cassera MB, Kenedy M, Radolf JD
  Infect. Immun. (2015) 83(8):3043-60 (PMC4496621)
• A Homology Model Reveals Novel Structural Features and an Immunodominant Surface Loop/Opsonic Target in the Treponema pallidum BamA Ortholog TP_0326.
  Luthra A, Anand A, Hawley KL, LeDoyt M, La Vake CJ, Caimano MJ, Cruz AR, Salazar JC, Radolf JD
  J. Bacteriol. (2015) 197(11):1906-20 (PMC4420902)
• Bipartite Topology of Treponema pallidum Repeat Proteins C/D and I: OUTER MEMBRANE INSERTION, TRIMERIZATION, AND PORIN FUNCTION REQUIRE A C-TERMINAL β-BARREL DOMAIN.
  Anand A, LeDoyt M, Karanian C, Luthra A, Koszelak-Rosenblum M, Malkowski MG, Puthenveetil R, Vinogradova O, Radolf JD
  J. Biol. Chem. (2015) 290(19):12313-31 (PMC4424362)

• 2014

• Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation.
  Iyer R, Caimano MJ, Luthra A, Axline D, Corona A, Iacobas DA, Radolf JD, Schwartz I
  Mol. Microbiol. (2014) 95(3):509-38 (PMC4429771)
• Xenodiagnosis for posttreatment Lyme disease syndrome: resolving the conundrum or adding to it?
  Bockenstedt LK, Radolf JD
  Clin. Infect. Dis. (2014) 58(7):946-8 (PMC3952604)
• Evaluation of the Borrelia burgdorferi BBA64 protein as a protective immunogen in mice.
  Brandt KS, Patton TG, Allard AS, Caimano MJ, Radolf JD, Gilmore RD
  Clin. Vaccine Immunol. (2014) 21(4):526-33 (PMC3993113)

• 2013

• HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete.
  Salman-Dilgimen A, Hardy PO, Radolf JD, Caimano MJ, Chaconas G
  PLoS Pathog. (2013) 9(12):e1003841 (PMC3868530)
• Structural modeling and physicochemical characterization provide evidence that P66 forms a β-barrel in the Borrelia burgdorferi outer membrane.
  Kenedy MR, Luthra A, Anand A, Dunn JP, Radolf JD, Akins DR
  J. Bacteriol. (2013) 196(4):859-72 (PMC3911182)
• Viscous dynamics of Lyme disease and syphilis spirochetes reveal flagellar torque and drag.
  Harman M, Vig DK, Radolf JD, Wolgemuth CW
  Biophys. J. (2013) 105(10):2273-80 (PMC3838743)
• MyD88 deficiency markedly worsens tissue inflammation and bacterial clearance in mice infected with Treponema pallidum, the agent of syphilis.
  Silver AC, Dunne DW, Zeiss CJ, Bockenstedt LK, Radolf JD, Salazar JC, Fikrig E
  PLoS ONE (2013) 8(8):e71388 (PMC3734110)
• The major outer sheath protein (Msp) of Treponema denticola has a bipartite domain architecture and exists as periplasmic and outer membrane-spanning conformers.
  Anand A, Luthra A, Edmond ME, Ledoyt M, Caimano MJ, Radolf JD
  J. Bacteriol. (2013) 195(9):2060-71 (PMC3624580)
• Pulling the trigger on lyme arthritis.
  Radolf JD
  J. Infect. Dis. (2013) 207(6):877-9 (PMC3571446)

• 2012

• Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments.
  Cruz AR, Ramirez LG, Zuluaga AV, Pillay A, Abreu C, Valencia CA, La Vake C, Cervantes JL, Dunham-Ems S, Cartun R, Mavilio D, Radolf JD, Salazar JC
  PLoS Negl Trop Dis (2012) 6(7):e1717 (PMC3398964)
• TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structure.
  Anand A, Luthra A, Dunham-Ems S, Caimano MJ, Karanian C, LeDoyt M, Cruz AR, Salazar JC, Radolf JD
  J. Bacteriol. (2012) 194(9):2321-33 (PMC3347077)
• Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmission.
  Dunham-Ems SM, Caimano MJ, Eggers CH, Radolf JD
  PLoS Pathog. (2012) 8(2):e1002532 (PMC3280991)
• The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue.
  Harman MW, Dunham-Ems SM, Caimano MJ, Belperron AA, Bockenstedt LK, Fu HC, Radolf JD, Wolgemuth CW
  Proc. Natl. Acad. Sci. U.S.A. (2012) 109(8):3059-64 (PMC3286914)
• CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi.
  Hawley KL, Olson CM, Iglesias-Pedraz JM, Navasa N, Cervantes JL, Caimano MJ, Izadi H, Ingalls RR, Pal U, Salazar JC, Radolf JD, Anguita J
  Proc. Natl. Acad. Sci. U.S.A. (2012) 109(4):1228-32 (PMC3268315)
• Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes.
  Radolf JD, Caimano MJ, Stevenson B, Hu LT
  Nat. Rev. Microbiol. (2012) 10(2):87-99 (PMC3313462)

• 2011

• The transition from closed to open conformation of Treponema pallidum outer membrane-associated lipoprotein TP0453 involves membrane sensing and integration by two amphipathic helices.
  Luthra A, Zhu G, Desrosiers DC, Eggers CH, Mulay V, Anand A, McArthur FA, Romano FB, Caimano MJ, Heuck AP, Malkowski MG, Radolf JD
  J. Biol. Chem. (2011) 286(48):41656-68 (PMC3308875)
• The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host.
  Eggers CH, Caimano MJ, Malizia RA, Kariu T, Cusack B, Desrosiers DC, Hazlett KR, Claiborne A, Pal U, Radolf JD
  Mol. Microbiol. (2011) 82(3):679-97 (PMC3226778)
• Serodiagnosis of syphilis in the recombinant era: reversal of fortune.
  Hoover KW, Radolf JD
  J. Infect. Dis. (2011) 204(9):1295-6 (PMC3182307)
• Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle.
  Pappas CJ, Iyer R, Petzke MM, Caimano MJ, Radolf JD, Schwartz I
  PLoS Pathog. (2011) 7(7):e1002102 (PMC3131272)
• The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks.
  Caimano MJ, Kenedy MR, Kairu T, Desrosiers DC, Harman M, Dunham-Ems S, Akins DR, Pal U, Radolf JD
  Infect. Immun. (2011) 79(8):3117-30 (PMC3147546)
• TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein.
  Desrosiers DC, Anand A, Luthra A, Dunham-Ems SM, LeDoyt M, Cummings MA, Eshghi A, Cameron CE, Cruz AR, Salazar JC, Caimano MJ, Radolf JD
  Mol. Microbiol. (2011) 80(6):1496-515 (PMC3115443)
• Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta.
  Cervantes JL, Dunham-Ems SM, La Vake CJ, Petzke MM, Sahay B, Sellati TJ, Radolf JD, Salazar JC
  Proc. Natl. Acad. Sci. U.S.A. (2011) 108(9):3683-8 (PMC3048123)

• 2010

• BB0844, an RpoS-regulated protein, is dispensable for Borrelia burgdorferi infectivity and maintenance in the mouse-tick infectious cycle.
  Banik S, Terekhova D, Iyer R, Pappas CJ, Caimano MJ, Radolf JD, Schwartz I
  Infect. Immun. (2010) 79(3):1208-17 (PMC3067486)
• A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes.
  Lee JH, Cai G, Panigrahi AK, Dunham-Ems S, Nguyen TN, Radolf JD, Asturias FJ, Günzl A
  Mol. Cell. Biol. (2010) 30(23):5502-13 (PMC2976424)
• Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum.
  Cox DL, Luthra A, Dunham-Ems S, Desrosiers DC, Salazar JC, Caimano MJ, Radolf JD
  Infect. Immun. (2010) 78(12):5178-94 (PMC2981305)
• Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi.
  Xu H, Caimano MJ, Lin T, He M, Radolf JD, Norris SJ, Gherardini F, Gheradini F, Wolfe AJ, Yang XF
  PLoS Pathog. (2010) 6(9):e1001104 (PMC2940757)
• Znu is the predominant zinc importer in Yersinia pestis during in vitro growth but is not essential for virulence.
  Desrosiers DC, Bearden SW, Mier I, Abney J, Paulley JT, Fetherston JD, Salazar JC, Radolf JD, Perry RD
  Infect. Immun. (2010) 78(12):5163-77 (PMC2981304)
• Secondary syphilis in cali, Colombia: new concepts in disease pathogenesis.
  Cruz AR, Pillay A, Zuluaga AV, Ramirez LG, Duque JE, Aristizabal GE, Fiel-Gan MD, Jaramillo R, Trujillo R, Valencia C, Jagodzinski L, Cox DL, Radolf JD, Salazar JC
  PLoS Negl Trop Dis (2010) 4(5):e690 (PMC2872645)
• Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum.
  Parsonage D, Desrosiers DC, Hazlett KR, Sun Y, Nelson KJ, Cox DL, Radolf JD, Poole LB
  Proc. Natl. Acad. Sci. U.S.A. (2010) 107(14):6240-5 (PMC2851974)
• Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment.
  Earnhart CG, Leblanc DV, Alix KE, Desrosiers DC, Radolf JD, Marconi RT
  Mol. Microbiol. (2010) 76(2):393-408 (PMC2917209)

• 2009

• CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance.
  Sahay B, Patsey RL, Eggers CH, Salazar JC, Radolf JD, Sellati TJ
  PLoS Pathog. (2009) 5(12):e1000687 (PMC2781632)
• Who is the BosR around here anyway?
  Samuels DS, Radolf JD
  Mol. Microbiol. (2009) 74(6):1295-9 (PMC3005592)
• Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks.
  Dunham-Ems SM, Caimano MJ, Pal U, Wolgemuth CW, Eggers CH, Balic A, Radolf JD
  J. Clin. Invest. (2009) 119(12):3652-65 (PMC2786795)
• Cryo-electron tomography elucidates the molecular architecture of Treponema pallidum, the syphilis spirochete.
  Izard J, Renken C, Hsieh CE, Desrosiers DC, Dunham-Ems S, La Vake C, Gebhardt LL, Limberger RJ, Cox DL, Marko M, Radolf JD
  J. Bacteriol. (2009) 191(24):7566-80 (PMC2786590)
• Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta.
  Salazar JC, Duhnam-Ems S, La Vake C, Cruz AR, Moore MW, Caimano MJ, Velez-Climent L, Shupe J, Krueger W, Radolf JD
  PLoS Pathog. (2009) 5(5):e1000444 (PMC2679197)
• Treponema pallidum, the stealth pathogen, changes, but how?
  Radolf JD, Desrosiers DC
  Mol. Microbiol. (2009) 72(5):1081-6 (PMC2975512)
• Local production of IFN-gamma by invariant NKT cells modulates acute Lyme carditis.
  Olson CM, Bates TC, Izadi H, Radolf JD, Huber SA, Boyson JE, Anguita J
  J. Immunol. (2009) 182(6):3728-34 (PMC2679988)
• Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals.
  Mulay VB, Caimano MJ, Iyer R, Dunham-Ems S, Liveris D, Petzke MM, Schwartz I, Radolf JD
  J. Bacteriol. (2009) 191(8):2783-94 (PMC2668432)

• 2008

• NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi.
  Tupin E, Benhnia MR, Kinjo Y, Patsey R, Lena CJ, Haller MC, Caimano MJ, Imamura M, Wong CH, Crotty S, Radolf JD, Sellati TJ, Kronenberg M
  Proc. Natl. Acad. Sci. U.S.A. (2008) 105(50):19863-8 (PMC2604993)
• The long strange trip of Borrelia burgdorferi outer-surface protein C.
  Radolf JD, Caimano MJ
  Mol. Microbiol. (2008) 69(1):1-4
• Anti-tumor necrosis factor-alpha activation of Borrelia burgdorferi spirochetes in antibiotic-treated murine Lyme borreliosis: an unproven conclusion.
  Wormser GP, Barthold SW, Shapiro ED, Dattwyler RJ, Bakken JS, Steere AC, Bockenstedt LK, Radolf JD
  J. Infect. Dis. (2008) 196(12):1865-6; author reply 1866-7

• 2007

• Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes.
  Cruz AR, Moore MW, La Vake CJ, Eggers CH, Salazar JC, Radolf JD
  Infect. Immun. (2007) 76(1):56-70 (PMC2223637)
• Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle.
  Caimano MJ, Iyer R, Eggers CH, Gonzalez C, Morton EA, Gilbert MA, Schwartz I, Radolf JD
  Mol. Microbiol. (2007) 65(5):1193-217 (PMC2967192)
• The general transition metal (Tro) and Zn2+ (Znu) transporters in Treponema pallidum: analysis of metal specificities and expression profiles.
  Desrosiers DC, Sun YC, Zaidi AA, Eggers CH, Cox DL, Radolf JD
  Mol. Microbiol. (2007) 65(1):137-52
• Single-dose prophylaxis against Lyme disease.
  Wormser GP, Dattwyler RJ, Shapiro ED, Dumler JS, O'Connell S, Radolf JD, Nadelman RB
  Lancet Infect Dis (2007) 7(6):371-3
• Assessment of the kinetics of Treponema pallidum dissemination into blood and tissues in experimental syphilis by real-time quantitative PCR.
  Salazar JC, Rathi A, Michael NL, Radolf JD, Jagodzinski LL
  Infect. Immun. (2007) 75(6):2954-8 (PMC1932886)
• Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis.
  Salazar JC, Cruz AR, Pope CD, Valderrama L, Trujillo R, Saravia NG, Radolf JD
  J. Infect. Dis. (2007) 195(6):879-87 (PMC2131710)
• Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production.
  Moore MW, Cruz AR, LaVake CJ, Marzo AL, Eggers CH, Salazar JC, Radolf JD
  Infect. Immun. (2007) 75(4):2046-62 (PMC1865718)

• 2006

• Borrelia burgdorferi BBA74, a periplasmic protein associated with the outer membrane, lacks porin-like properties.
  Mulay V, Caimano MJ, Liveris D, Desrosiers DC, Radolf JD, Schwartz I
  J. Bacteriol. (2006) 189(5):2063-8 (PMC1855751)
• The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks.
  Li X, Pal U, Ramamoorthi N, Liu X, Desrosiers DC, Eggers CH, Anderson JF, Radolf JD, Fikrig E
  Mol. Microbiol. (2006) 63(3):694-710
• Sigma factor selectivity in Borrelia burgdorferi: RpoS recognition of the ospE/ospF/elp promoters is dependent on the sequence of the -10 region.
  Eggers CH, Caimano MJ, Radolf JD
  Mol. Microbiol. (2006) 59(6):1859-75

• 2005

• Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genes.
  Caimano MJ, Eggers CH, Gonzalez CA, Radolf JD
  J. Bacteriol. (2005) 187(22):7845-52 (PMC1280317)
• TP0453, a concealed outer membrane protein of Treponema pallidum, enhances membrane permeability.
  Hazlett KR, Cox DL, Decaffmeyer M, Bennett MP, Desrosiers DC, La Vake CJ, La Vake ME, Bourell KW, Robinson EJ, Brasseur R, Radolf JD
  J. Bacteriol. (2005) 187(18):6499-508 (PMC1236642)
• Lipoprotein-dependent and -independent immune responses to spirochetal infection.
  Salazar JC, Pope CD, Moore MW, Pope J, Kiely TG, Radolf JD
  Clin. Diagn. Lab. Immunol. (2005) 12(8):949-58 (PMC1182186)
• Signaling through CD14 attenuates the inflammatory response to Borrelia burgdorferi, the agent of Lyme disease.
  Benhnia MR, Wroblewski D, Akhtar MN, Patel RA, Lavezzi W, Gangloff SC, Goyert SM, Caimano MJ, Radolf JD, Sellati TJ
  J. Immunol. (2005) 174(3):1539-48

• 2004

• RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants.
  Caimano MJ, Eggers CH, Hazlett KR, Radolf JD
  Infect. Immun. (2004) 72(11):6433-45 (PMC523033)
• Analysis of promoter elements involved in the transcriptional initiation of RpoS-dependent Borrelia burgdorferi genes.
  Eggers CH, Caimano MJ, Radolf JD
  J. Bacteriol. (2004) 186(21):7390-402 (PMC523197)
• Experimental assessment of the roles of linear plasmids lp25 and lp28-1 of Borrelia burgdorferi throughout the infectious cycle.
  Grimm D, Eggers CH, Caimano MJ, Tilly K, Stewart PE, Elias AF, Radolf JD, Rosa PA
  Infect. Immun. (2004) 72(10):5938-46 (PMC517563)
• Borrelia burgdorferi outer surface protein (osp) B expression independent of ospA.
  Liang FT, Caimano MJ, Radolf JD, Fikrig E
  Microb. Pathog. (2004) 37(1):35-40

• 2003

• Borrelia burgdorferi transcriptome in the central nervous system of non-human primates.
  Narasimhan S, Caimano MJ, Liang FT, Santiago F, Laskowski M, Philipp MT, Pachner AR, Radolf JD, Fikrig E, Camaino MJ
  Proc. Natl. Acad. Sci. U.S.A. (2003) 100(26):15953-8 (PMC307674)
• Coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migrans.
  Salazar JC, Pope CD, Sellati TJ, Feder HM, Kiely TG, Dardick KR, Buckman RL, Moore MW, Caimano MJ, Pope JG, Krause PJ, Radolf JD
  J. Immunol. (2003) 171(5):2660-70
• Increasing health burden of human babesiosis in endemic sites.
  Krause PJ, McKay K, Gadbaw J, Christianson D, Closter L, Lepore T, Telford SR, Sikand V, Ryan R, Persing D, Radolf JD, Spielman A
  Am. J. Trop. Med. Hyg. (2003) 68(4):431-6
• A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host.
  Purser JE, Lawrenz MB, Caimano MJ, Howell JK, Radolf JD, Norris SJ
  Mol. Microbiol. (2003) 48(3):753-64
• The Treponema pallidum tro operon encodes a multiple metal transporter, a zinc-dependent transcriptional repressor, and a semi-autonomously expressed phosphoglycerate mutase.
  Hazlett KR, Rusnak F, Kehres DG, Bearden SW, La Vake CJ, La Vake ME, Maguire ME, Perry RD, Radolf JD
  J. Biol. Chem. (2003) 278(23):20687-94
• Adaptation of the Lyme disease spirochaete to the mammalian host environment results in enhanced glycosaminoglycan and host cell binding.
  Parveen N, Caimano M, Radolf JD, Leong JM
  Mol. Microbiol. (2003) 47(5):1433-44
• Characterization of the stringent response and rel(Bbu) expression in Borrelia burgdorferi.
  Bugrysheva J, Dobrikova EY, Sartakova ML, Caimano MJ, Daniels TJ, Radolf JD, Godfrey HP, Cabello FC
  J. Bacteriol. (2003) 185(3):957-65 (PMC142832)

• 2002

• The immune response to infection with Treponema pallidum, the stealth pathogen.
  Salazar JC, Hazlett KR, Radolf JD
  Microbes Infect. (2002) 4(11):1133-40
• PCR-based identification of bacteria associated with endodontic infections.
  Fouad AF, Barry J, Caimano M, Clawson M, Zhu Q, Carver R, Hazlett K, Radolf JD
  J. Clin. Microbiol. (2002) 40(9):3223-31 (PMC130810)
• Cellular immunity, but not gamma interferon, is essential for resolution of Babesia microti infection in BALB/c mice.
  Clawson ML, Paciorkowski N, Rajan TV, La Vake C, Pope C, La Vake M, Wikel SK, Krause PJ, Radolf JD
  Infect. Immun. (2002) 70(9):5304-6 (PMC128260)
• Contribution of neelaredoxin to oxygen tolerance by Treponema pallidum.
  Hazlett KR, Cox DL, Sikkink RA, Auch'ere F, Rusnak F, Radolf JD
  Meth. Enzymol. (2002) 353:140-56
• Identification of loci critical for replication and compatibility of a Borrelia burgdorferi cp32 plasmid and use of a cp32-based shuttle vector for the expression of fluorescent reporters in the lyme disease spirochaete.
  Eggers CH, Caimano MJ, Clawson ML, Miller WG, Samuels DS, Radolf JD
  Mol. Microbiol. (2002) 43(2):281-95
• Disease-specific diagnosis of coinfecting tickborne zoonoses: babesiosis, human granulocytic ehrlichiosis, and Lyme disease.
  Krause PJ, McKay K, Thompson CA, Sikand VK, Lentz R, Lepore T, Closter L, Christianson D, Telford SR, Persing D, Radolf JD, Spielman A
  Clin. Infect. Dis. (2002) 34(9):1184-91
• The crystal structure of Zn(II)-free Treponema pallidum TroA, a periplasmic metal-binding protein, reveals a closed conformation.
  Lee YH, Dorwart MR, Hazlett KR, Deka RK, Norgard MV, Radolf JD, Hasemann CA
  J. Bacteriol. (2002) 184(8):2300-4 (PMC134957)
• Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background.
  Elias AF, Stewart PE, Grimm D, Caimano MJ, Eggers CH, Tilly K, Bono JL, Akins DR, Radolf JD, Schwan TG, Rosa P
  Infect. Immun. (2002) 70(4):2139-50 (PMC127854)

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