Publications: Arthur Günzl

• 2021

• A distinct complex of PRP19-related and trypanosomatid-specific proteins is required for pre-mRNA splicing in trypanosomes.
  Srivastava A, Ambrósio DL, Tasak M, Gosavi U, Günzl A
  Nucleic acids research (2021) 49(22):12929-12942 PMC5343452 10.1093/nar/gkab1152

• 2017

• Metacyclic VSG expression site promoters are recognized by the same general transcription factor that is required for RNA polymerase I transcription of bloodstream expression sites.
  Kolev NG, Günzl A, Tschudi C
  Mol. Biochem. Parasitol. (2017) 216:52-55 (PMC5582990)
• Correction for Kirkham et al., "Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A".
  Kirkham JK, Park SH, Nguyen TN, Lee JH, Günzl A
  Mol. Cell. Biol. (2017) 37(12): (PMC5452717)

• 2016

• Cyclin-Dependent Kinase CRK9, Required for Spliced Leader trans Splicing of Pre-mRNA in Trypanosomes, Functions in a Complex with a New L-Type Cyclin and a Kinetoplastid-Specific Protein.
  Badjatia N, Park SH, Ambrósio DL, Kirkham JK, Günzl A
  PLoS Pathog. (2016) 12(3):e1005498 (PMC4783070)

• 2015

• Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A.
  Kirkham JK, Park SH, Nguyen TN, Lee JH, Günzl A
  Mol. Cell. Biol. (2015) 36(1):95-107 (PMC4702606)

• 2014

• The spliceosomal PRP19 complex of trypanosomes.
  Ambrósio DL, Badjatia N, Günzl A
  Mol. Microbiol. (2014) 95(5):885-901 (PMC4374492)
• Mono-allelic VSG expression by RNA polymerase I in Trypanosoma brucei: expression site control from both ends?
  Günzl A, Kirkham JK, Nguyen TN, Badjatia N, Park SH
  Gene (2014) 556(1):68-73 (PMC4272636)
• Phosphorylation of the TATA-binding protein activates the spliced leader silencing pathway in Trypanosoma brucei.
  Hope R, Ben-Mayor E, Friedman N, Voloshin K, Biswas D, Matas D, Drori Y, Günzl A, Michaeli S
  Sci Signal (2014) 7(341):ra85
• A new strategy of RNA interference that targets heterologous sequences reveals CITFA1 as an essential component of class I transcription factor A in Trypanosoma brucei.
  Park SH, Nguyen BN, Kirkham JK, Nguyen TN, Günzl A
  Eukaryotic Cell (2014) 13(6):785-95 (PMC4054280)

• 2013

• Promoter occupancy of the basal class I transcription factor A differs strongly between active and silent VSG expression sites in Trypanosoma brucei.
  Nguyen TN, Müller LS, Park SH, Siegel TN, Günzl A
  Nucleic Acids Res. (2013) 42(5):3164-76 (PMC3950698)
• Trypanosoma brucei harbours a divergent XPB helicase paralogue that is specialized in nucleotide excision repair and conserved among kinetoplastid organisms.
  Badjatia N, Nguyen TN, Lee JH, Günzl A
  Mol. Microbiol. (2013) 90(6):1293-308 (PMC3864625)
• Trypanosome cdc2-related kinase 9 controls spliced leader RNA cap4 methylation and phosphorylation of RNA polymerase II subunit RPB1.
  Badjatia N, Ambrósio DL, Lee JH, Günzl A
  Mol. Cell. Biol. (2013) 33(10):1965-75 (PMC3647971)

• 2012

• Characterization of a novel class I transcription factor A (CITFA) subunit that is indispensable for transcription by the multifunctional RNA polymerase I of Trypanosoma brucei.
  Nguyen TN, Nguyen BN, Lee JH, Panigrahi AK, Günzl A
  Eukaryotic Cell (2012) 11(12):1573-81 (PMC3536272)

• 2011

• Development of an efficient in vitro transcription system for bloodstream form Trypanosoma brucei reveals life cycle-independent functionality of class I transcription factor A.
  Park SH, Nguyen TN, Günzl A
  Mol. Biochem. Parasitol. (2011) 181(1):29-36 (PMC3215803)
• Transcription by the multifunctional RNA polymerase I in Trypanosoma brucei functions independently of RPB7.
  Park SH, Nguyen TN, Kirkham JK, Lee JH, Günzl A
  Mol. Biochem. Parasitol. (2011) 180(1):35-42 (PMC3171583)

• 2010

• A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes.
  Lee JH, Cai G, Panigrahi AK, Dunham-Ems S, Nguyen TN, Radolf JD, Asturias FJ, Günzl A
  Mol. Cell. Biol. (2010) 30(23):5502-13 (PMC2976424)
• The pre-mRNA splicing machinery of trypanosomes: complex or simplified?
  Günzl A
  Eukaryotic Cell (2010) 9(8):1159-70 (PMC2918933)

• 2009

• Spliceosomal proteomics in Trypanosoma brucei reveal new RNA splicing factors.
  Luz Ambrósio D, Lee JH, Panigrahi AK, Nguyen TN, Cicarelli RM, Günzl A
  Eukaryotic Cell (2009) 8(7):990-1000 (PMC2708463)
• Transcriptionally active TFIIH of the early-diverged eukaryote Trypanosoma brucei harbors two novel core subunits but not a cyclin-activating kinase complex.
  Lee JH, Jung HS, Günzl A
  Nucleic Acids Res. (2009) 37(11):3811-20 (PMC2699521)
• Tandem affinity purification of proteins.
  Günzl A, Schimanski B
  Curr Protoc Protein Sci (2009) Chapter 19:Unit 19.19

• 2007

• Multifunctional class I transcription in Trypanosoma brucei depends on a novel protein complex.
  Brandenburg J, Schimanski B, Nogoceke E, Nguyen TN, Padovan JC, Chait BT, Cross GA, Günzl A
  EMBO J. (2007) 26(23):4856-66 (PMC2099468)
• Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL3B.
  Reynolds JM, El Bissati K, Brandenburg J, Günzl A, Mamoun CB
  BMC Clin Pharmacol (2007) 7:13 (PMC2213633)
• Active RNA polymerase I of Trypanosoma brucei harbors a novel subunit essential for transcription.
  Nguyen TN, Schimanski B, Günzl A
  Mol. Cell. Biol. (2007) 27(17):6254-63 (PMC1952147)
• Purification of components of the translation elongation factor complex of Plasmodium falciparum by tandem affinity purification.
  Takebe S, Witola WH, Schimanski B, Günzl A, Ben Mamoun C
  Eukaryotic Cell (2007) 6(4):584-91 (PMC1865644)
• Spliced leader RNA gene transcription in Trypanosoma brucei requires transcription factor TFIIH.
  Lee JH, Nguyen TN, Schimanski B, Günzl A
  Eukaryotic Cell (2007) 6(4):641-9 (PMC1865645)

• 2006

• Purification of an eight subunit RNA polymerase I complex in Trypanosoma brucei.
  Nguyen TN, Schimanski B, Zahn A, Klumpp B, Günzl A
  Mol. Biochem. Parasitol. (2006) 149(1):27-37
• A TFIIB-like protein is indispensable for spliced leader RNA gene transcription in Trypanosoma brucei.
  Schimanski B, Brandenburg J, Nguyen TN, Caimano MJ, Günzl A
  Nucleic Acids Res. (2006) 34(6):1676-84 (PMC1409817)

• 2005

• Highly efficient tandem affinity purification of trypanosome protein complexes based on a novel epitope combination.
  Schimanski B, Nguyen TN, Günzl A
  Eukaryotic Cell (2005) 4(11):1942-50 (PMC1287860)
• Characterization of a multisubunit transcription factor complex essential for spliced-leader RNA gene transcription in Trypanosoma brucei.
  Schimanski B, Nguyen TN, Günzl A
  Mol. Cell. Biol. (2005) 25(16):7303-13 (PMC1190248)

• 2004

• Failure to detect binding of Trypanosoma brucei SNAPc to U2 and U6 snRNA gene sequences by in vitro transcription competition and pull-down assays.
  Schimanski B, Ma L, Günzl A
  Mol. Biochem. Parasitol. (2004) 137(2):293-6
• The Trypanosoma brucei spliced leader RNA and rRNA gene promoters have interchangeable TbSNAP50-binding elements.
  Schimanski B, Laufer G, Gontcharova L, Günzl A
  Nucleic Acids Res. (2004) 32(2):700-9 (PMC373353)