Publications: Dennis Wright

• 2023

• HMGB2 is a potential diagnostic marker and therapeutic target for liver fibrosis and cirrhosis.
  Huang Y, Liangpunsakul S, Rudraiah S, Ma J, Keshipeddy SK, Wright D, Costa A, Burgess D, Zhang Y, Huda N, Wang L, Yang Z
  Hepatology communications (2023) 7(11): PMC3335123 10.1097/HC9.0000000000000299
• Incorporation of 53BP1 into phase-separated bodies in cancer cells during aberrant mitosis.
  Bleiler M, Cyr A, Wright DL, Giardina C
  Journal of cell science (2023) 136(1): PMC3664841 10.1126/science.1231573

• 2022

• Viral Nucleases from Herpesviruses and Coronavirus in Recombination and Proofreading: Potential Targets for Antiviral Drug Discovery.
  Wright LR, Wright DL, Weller SK
  Viruses (2022) 14(7): PMC8640510 10.1038/s41418-021-00900-1
• Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.
  Krucinska J, Lombardo MN, Erlandsen H, Estrada A, Si D, Viswanathan K, Wright DL
  Communications biology (2022) 5(1):459 PMC3069751 10.1107/S0907444911001314
• Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus.
  Wang S, Reeve SM, Holt GT, Ojewole AA, Frenkel MS, Gainza P, Keshipeddy S, Fowler VG, Wright DL, Donald BR
  PLoS computational biology (2022) 18(2):e1009855 PMC2144501 10.1002/prot.22383
• Two-Metal Ion-Dependent Enzymes as Potential Antiviral Targets in Human Herpesviruses.
  DiScipio KA, Weerasooriya S, Szczepaniak R, Hazeen A, Wright LR, Wright DL, Weller SK
  mBio (2022) 13(1):e0322621 PMC2447070 10.1128/JVI.00455-08

• 2020

• Novel guanidine compounds inhibit platelet-derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation.
  Medved J, Wood WM, van Heyst MD, Sherafat A, Song JY, Sakya S, Wright DL, Nishiyama A
  Glia (2020) 69(3):792-811 PMC7856068 10.1002/glia.23930
• Targeting the pregnane X receptor using microbial metabolite mimicry.
  Dvořák Z, Kopp F, Costello CM, Kemp JS, Li H, Vrzalová A, Štěpánková M, Bartoňková I, Jiskrová E, Poulíková K, Vyhlídalová B, Nordstroem LU, Karunaratne CV, Ranhotra HS, Mun KS, Naren AP, Murray IA, Perdew GH, Brtko J, Toporova L, Schön A, Wallace BD, Walton WG, Redinbo MR, Sun K, Beck A, Kortagere S, Neary MC, Chandran A, Vishveshwara S, Cavalluzzi MM, Lentini G, Cui JY, Gu H, March JC, Chatterjee S, Matson A, Wright D, Flannigan KL, Hirota SA, Sartor RB, Mani S
  EMBO molecular medicine (2020) 12(4):e11621 PMC7136958 10.15252/emmm.201911621

• 2019

• Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate.
  Krucinska J, Lombardo MN, Erlandsen H, Hazeen A, Duay SS, Pattis JG, Robinson VL, May ER, Wright DL
  Scientific reports (2019) 9(1):17106 PMC6863902 10.1038/s41598-019-53301-3
• Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant .
  Reeve SM, Si D, Krucinska J, Yan Y, Viswanathan K, Wang S, Holt GT, Frenkel MS, Ojewole AA, Estrada A, Agabiti SS, Alverson JB, Gibson ND, Priestley ND, Wiemer AJ, Donald BR, Wright DL
  ACS infectious diseases (2019) 5(11):1896-1906 PMC7025792 10.1021/acsinfecdis.9b00222
• Structure guided in-vitro to in-vivo pharmacokinetic optimization of propargyl-linked antifolates.
  Lombardo MN, G-Dayanandan N, Keshipeddy S, Zhou W, Si D, Reeve SM, Alverson J, Barney P, Walker L, Hoody J, Priestley N, Obach RS, Wright DL
  Drug Metab. Dispos. (2019) : 10.1124/dmd.119.086504
• Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents.
  Hajian B, Scocchera E, Shoen C, Krucinska J, Viswanathan K, G-Dayanandan N, Erlandsen H, Estrada A, Mikušová K, Korduláková J, Cynamon M, Wright D
  Cell chemical biology (2019) 26(6):781-791.e6 PMC6588435 10.1016/j.chembiol.2019.02.013
• Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens.
  Krucinska J, Falcone E, Erlandsen H, Hazeen A, Lombardo MN, Estrada A, Robinson VL, Anderson AC, Wright DL
  Biochemistry (2019) 58(9):1188-1197 PMC6511404 10.1021/acs.biochem.8b01298
• Tropolone-induced effects on the unfolded protein response pathway and apoptosis in multiple myeloma cells are dependent on iron.
  Haney SL, Varney ML, Safranek HR, Chhonker YS, G-Dayanandan N, Talmon G, Murry DJ, Wiemer AJ, Wright DL, Holstein SA
  Leukemia research (2019) 77:17-27 PMC6456044 10.1016/j.leukres.2018.12.007
• Post-Glycosylation Diversification (PGD): An Approach for Assembling Collections of Glycosylated Small Molecules.
  Cannone Z, Shaqra AM, Lorenc C, Henowitz L, Keshipeddy S, Robinson VL, Zweifach A, Wright D, Peczuh MW
  ACS combinatorial science (2019) 21(3):192-197 10.1021/acscombsci.8b00139

• 2018

• Spindle Assembly Disruption and Cancer Cell Apoptosis with a CLTC-Binding Compound.
  Bond MJ, Bleiler M, Harrison LE, Scocchera EW, Nakanishi M, G-Dayanan N, Keshipeddy S, Rosenberg DW, Wright DL, Giardina C
  Mol. Cancer Res. (2018) 16(9):1361-1372 (PMC6125173) 10.1158/1541-7786.MCR-18-0178

• 2017

• High-mobility-group protein 2 regulated by microRNA-127 and small heterodimer partner modulates pluripotency of mouse embryonic stem cells and liver tumor initiating cells.
  Zhao Y, Yang Z, Wu J, Wu R, Keshipeddy SK, Wright D, Wang L
  Hepatol Commun (2017) 1(8):816-830 (PMC5678910) 10.1002/hep4.1086
• Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells.
  Haney SL, Allen C, Varney ML, Dykstra KM, Falcone ER, Colligan SH, Hu Q, Aldridge AM, Wright DL, Wiemer AJ, Holstein SA
  Oncotarget (2017) 8(44):76085-76098 (PMC5652688) 10.18632/oncotarget.18543
• USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms.
  Pozhidaeva A, Valles G, Wang F, Wu J, Sterner DE, Nguyen P, Weinstock J, Kumar KGS, Kanyo J, Wright D, Bezsonova I
  Cell Chem Biol (2017) 24(12):1501-1512.e5 10.1016/j.chembiol.2017.09.004
• The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus.
  Grady LM, Szczepaniak R, Murelli RP, Masaoka T, Le Grice SFJ, Wright DL, Weller SK
  J. Virol. (2017) 91(23): (PMC5686714) 10.1128/JVI.01380-17
• Characterization of trimethoprim resistant dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates.
  Cammarata M, Thyer R, Lombardo M, Anderson A, Wright D, Ellington A, Brodbelt JS
  Chem Sci (2017) 8(5):4062-4072 (PMC6020862) 10.1039/c6sc05235e
• Pharmaceutical analysis of a novel propargyl-linked antifolate antibiotic in the mouse.
  Hoody J, Alverson JB, Keshipeddy S, Barney PA, Walker L, Anderson AC, Wright DL, Priestley ND
  J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2017) 1051:54-59 (PMC5635995) 10.1016/j.jchromb.2017.02.026

• 2016

• Direct Substitution of Arylalkynyl Carbinols Provides Access to Diverse Terminal Acetylene Building Blocks.
  G-Dayanandan N, Scocchera EW, Keshipeddy S, Jones HF, Anderson AC, Wright DL
  Org. Lett. (2016) 19(1):142-145 (PMC5253071) 10.1021/acs.orglett.6b03438
• MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.
  Reeve SM, Scocchera EW, G-Dayanadan N, Keshipeddy S, Krucinska J, Hajian B, Ferreira J, Nailor M, Aeschlimann J, Wright DL, Anderson AC
  Cell Chem Biol (2016) 23(12):1458-1467 (PMC5228619) 10.1016/j.chembiol.2016.11.007
• Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis.
  Li J, Falcone ER, Holstein SA, Anderson AC, Wright DL, Wiemer AJ
  Pharmacol. Res. (2016) 113(Pt A):438-448 (PMC5107114) 10.1016/j.phrs.2016.09.020
• Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.
  Lombardo MN, G-Dayanandan N, Wright DL, Anderson AC
  ACS Infect Dis (2016) 2(2):149-56 (PMC5108240) 10.1021/acsinfecdis.5b00129
• Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.
  Hajian B, Scocchera E, Keshipeddy S, G-Dayanandan N, Shoen C, Krucinska J, Reeve S, Cynamon M, Anderson AC, Wright DL
  PLoS ONE (2016) 11(8):e0161740 (PMC5006990) 10.1371/journal.pone.0161740
• Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.
  Scocchera E, Reeve SM, Keshipeddy S, Lombardo MN, Hajian B, Sochia AE, Alverson JB, Priestley ND, Anderson AC, Wright DL
  ACS Med Chem Lett (2016) 7(7):692-6 (PMC4948012) 10.1021/acsmedchemlett.6b00120
• Antibacterial Antifolates: From Development through Resistance to the Next Generation.
  Estrada A, Wright DL, Anderson AC
  Cold Spring Harb Perspect Med (2016) 6(8): (PMC4968165) 10.1101/cshperspect.a028324
• Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.
  Reeve SM, Scocchera E, Ferreira JJ, G-Dayanandan N, Keshipeddy S, Wright DL, Anderson AC
  J. Med. Chem. (2016) 59(13):6493-500 (PMC5257293) 10.1021/acs.jmedchem.6b00688
• Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301.
  Chopra A, Bond MJ, Bleiler M, Yeagley M, Wright D, Giardina C
  PLoS ONE (2016) 11(4):e0153818 (PMC4838221) 10.1371/journal.pone.0153818

• 2015

• The challenge of resistance in antimicrobial drug development.
  Anderson AC, Wright DL
  Future Microbiol (2015) 10(11):1709-10 (PMC4733617) 10.2217/fmb.15.75
• Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus.
  Keshipeddy S, Reeve SM, Anderson AC, Wright DL
  J. Am. Chem. Soc. (2015) 137(28):8983-90 (PMC4733634) 10.1021/jacs.5b01442
• Measuring propargyl-linked drug populations inside bacterial cells, and their interaction with a dihydrofolate reductase target, by Raman microscopy.
  Heidari-Torkabadi H, Che T, Lombardo MN, Wright DL, Anderson AC, Carey PR
  Biochemistry (2015) 54(17):2719-26 10.1021/acs.biochem.5b00202

• 2014

• Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.
  Lamb KM, Lombardo MN, Alverson J, Priestley ND, Wright DL, Anderson AC
  Antimicrob. Agents Chemother. (2014) 58(12):7484-91 (PMC4249513) 10.1128/AAC.03555-14
• Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.
  Ononye SN, VanHeyst MD, Oblak EZ, Zhou W, Ammar M, Anderson AC, Wright DL
  ACS Med Chem Lett (2014) 4(8):757-61 (PMC4027479) 10.1021/ml400158k
• Antifolate agents: a patent review (2010 - 2013).
  Anderson AC, Wright DL
  Expert Opin Ther Pat (2014) 24(6):687-97 10.1517/13543776.2014.898062
• Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells.
  Ononye SN, Vanheyst MD, Giardina C, Wright DL, Anderson AC
  Bioorg. Med. Chem. (2014) 22(7):2188-93 (PMC4011186) 10.1016/j.bmc.2014.02.018
• Cyclopropene cycloadditions with annulated furans: total synthesis of (+)- and (-)-frondosin B and (+)-frondosin A.
  Oblak EZ, VanHeyst MD, Li J, Wiemer AJ, Wright DL
  J. Am. Chem. Soc. (2014) 136(11):4309-15 10.1021/ja413106t
• Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata.
  G-Dayanandan N, Paulsen JL, Viswanathan K, Keshipeddy S, Lombardo MN, Zhou W, Lamb KM, Sochia AE, Alverson JB, Priestley ND, Wright DL, Anderson AC
  J. Med. Chem. (2014) 57(6):2643-56 (PMC3983340) 10.1021/jm401916j

• 2013

• Development of intestinal organoids as tissue surrogates: cell composition and the epigenetic control of differentiation.
  Cao L, Kuratnik A, Xu W, Gibson JD, Kolling F, Falcone ER, Ammar M, Van Heyst MD, Wright DL, Nelson CE, Giardina C
  Mol. Carcinog. (2013) 54(3):189-202 10.1002/mc.22089
• Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase.
  Lamb KM, G-Dayanandan N, Wright DL, Anderson AC
  Biochemistry (2013) 52(41):7318-26 (PMC3855305) 10.1021/bi400852h
• Stereodivergent resolution of oxabicyclic ketones: preparation of key intermediates for platensimycin and other natural products.
  VanHeyst MD, Oblak EZ, Wright DL
  J. Org. Chem. (2013) 78(20):10555-9 10.1021/jo4017502
• The tandem ring opening/ring closing metathesis route to oxaspirocycles: an approach to phelligridin G.
  Cooper HD, Wright DL
  Molecules (2013) 18(2):2438-48 (PMC6269797) 10.3390/molecules18022438
• Identification of novel compounds that enhance colon cancer cell sensitivity to inflammatory apoptotic ligands.
  Chopra AS, Kuratnik A, Scocchera EW, Wright DL, Giardina C
  Cancer Biol. Ther. (2013) 14(5):436-49 (PMC3672188) 10.4161/cbt.23787
• Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.
  Paulsen JL, Viswanathan K, Wright DL, Anderson AC
  Bioorg. Med. Chem. Lett. (2013) 23(5):1279-84 (PMC3579541) 10.1016/j.bmcl.2013.01.008

• 2012

• Nonpeptidic lysosomal modulators derived from z-phe-ala-diazomethylketone for treating protein accumulation diseases.
  Viswanathan K, Hoover DJ, Hwang J, Wisniewski ML, Ikonne US, Bahr BA, Wright DL
  ACS Med Chem Lett (2012) 3(11):920-4 (PMC4025860) 10.1021/ml300197h
• Viridin analogs derived from steroidal building blocks.
  Viswanathan K, Ononye SN, Cooper HD, Kyle Hadden M, Anderson AC, Wright DL
  Bioorg. Med. Chem. Lett. (2012) 22(22):6919-22 10.1016/j.bmcl.2012.09.015
• The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs.
  Oblak EZ, Bolstad ES, Ononye SN, Priestley ND, Hadden MK, Wright DL
  Org. Biomol. Chem. (2012) 10(43):8597-604 10.1039/c2ob26553b
• Acetylenic linkers in lead compounds: a study of the stability of the propargyl-linked antifolates.
  Zhou W, Viswanathan K, Hill D, Anderson AC, Wright DL
  Drug Metab. Dispos. (2012) 40(10):2002-8 (PMC3463820) 10.1124/dmd.112.046870
• Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance.
  Frey KM, Viswanathan K, Wright DL, Anderson AC
  Antimicrob. Agents Chemother. (2012) 56(7):3556-62 (PMC3393473) 10.1128/AAC.06263-11
• Toward new therapeutics for skin and soft tissue infections: propargyl-linked antifolates are potent inhibitors of MRSA and Streptococcus pyogenes.
  Viswanathan K, Frey KM, Scocchera EW, Martin BD, Swain Iii PW, Alverson JB, Priestley ND, Anderson AC, Wright DL
  PLoS ONE (2012) 7(2):e29434 (PMC3274548) 10.1371/journal.pone.0029434

• 2011

• Antifolate agents: a patent review (2006 - 2010).
  Wright DL, Anderson AC
  Expert Opin Ther Pat (2011) 21(9):1293-308 (PMC3156879) 10.1517/13543776.2011.587804
• Tandem metathesis reactions of oxabicyclo[2.2.1]heptenes: studies on the spirocyclic core of cyclopamine.
  Oblak EZ, G-Dayanandan N, Wright DL
  Org. Lett. (2011) 13(9):2433-5 10.1021/ol200706f
• Highly substituted oxabicyclic derivatives from furan: synthesis of (±)-platensimycin.
  Oblak EZ, Wright DL
  Org. Lett. (2011) 13(9):2263-5 10.1021/ol2005775

• 2010

• Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites.
  Britton M, Lucas MM, Downey SL, Screen M, Pletnev AA, Verdoes M, Tokhunts RA, Amir O, Goddard AL, Pelphrey PM, Wright DL, Overkleeft HS, Kisselev AF
  Chem. Biol. (2010) 16(12):1278-89 (PMC2807417) 10.1016/j.chembiol.2009.11.015

• 2009

• Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase.
  Frey KM, Lombardo MN, Wright DL, Anderson AC
  J. Struct. Biol. (2009) 170(1):93-7 (PMC2841211) 10.1016/j.jsb.2009.12.011
• In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.
  Paulsen JL, Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC
  Bioorg. Med. Chem. (2009) 17(14):4866-72 (PMC2724765) 10.1016/j.bmc.2009.06.021
• Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.
  Frey KM, Liu J, Lombardo MN, Bolstad DB, Wright DL, Anderson AC
  J. Mol. Biol. (2009) 387(5):1298-308 (PMC2723953) 10.1016/j.jmb.2009.02.045
• Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity.
  Sundstrom TJ, Anderson AC, Wright DL
  Org. Biomol. Chem. (2009) 7(5):840-50 10.1039/b819067b
• Towards new antifolates targeting eukaryotic opportunistic infections.
  Liu J, Bolstad DB, Bolstad ES, Wright DL, Anderson AC
  Eukaryotic Cell (2009) 8(4):483-6 (PMC2669212) 10.1128/EC.00298-08
• Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors.
  Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC
  Chem Biol Drug Des (2009) 73(1):62-74 (PMC2838185) 10.1111/j.1747-0285.2008.00745.x

• 2008

• Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase.
  Beierlein JM, Frey KM, Bolstad DB, Pelphrey PM, Joska TM, Smith AE, Priestley ND, Wright DL, Anderson AC
  J. Med. Chem. (2008) 51(23):7532-40 (PMC2645930) 10.1021/jm800776a
• Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.
  Bolstad DB, Bolstad ES, Frey KM, Wright DL, Anderson AC
  J. Med. Chem. (2008) 51(21):6839-52 (PMC2584871) 10.1021/jm8009124
• Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase.
  Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC
  Chem. Biol. (2008) 15(9):990-6 (PMC2610858) 10.1016/j.chembiol.2008.07.013
• Dihydrofolate reductase inhibitors: developments in antiparasitic chemotherapy.
  Bolstad DB, Bolstad ES, Wright DL, Anderson AC
  Expert Opin Ther Pat (2008) 18(2):143-57 10.1517/13543776.18.2.143

• 2007

• Highly efficient ligands for dihydrofolate reductase from Cryptosporidium hominis and Toxoplasma gondii inspired by structural analysis.
  Pelphrey PM, Popov VM, Joska TM, Beierlein JM, Bolstad ES, Fillingham YA, Wright DL, Anderson AC
  J. Med. Chem. (2007) 50(5):940-50 10.1021/jm061027h

• 2006

• The application of cathodic reductions and anodic oxidations in the synthesis of complex molecules.
  Sperry JB, Wright DL
  Chem Soc Rev (2006) 35(7):605-21 10.1039/b512308a
• Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative.
  Popov VM, Chan DC, Fillingham YA, Atom Yee W, Wright DL, Anderson AC
  Bioorg. Med. Chem. Lett. (2006) 16(16):4366-70 10.1016/j.bmcl.2006.05.047
• The cycloaddition strategy for the synthesis of natural products containing carbocyclic seven-membered rings.
  Battiste MA, Pelphrey PM, Wright DL
  Chemistry (2006) 12(13):3438-47 10.1002/chem.200501083

• 2005

• Electrochemical annulation of five-membered rings through dearomatization of furans and thiophenes.
  Sperry JB, Ghiviriga I, Wright DL
  Chem. Commun. (Camb.) (2005) (2):194-6 10.1039/b513532j
• Furans, thiophenes and related heterocycles in drug discovery.
  Sperry JB, Wright DL
  Curr Opin Drug Discov Devel (2005) 8(6):723-40
• Photocurable hard and porous biomaterials from ROMP precursors cross-linked with diyl radicals.
  Enholm E, Joshi A, Wright DL
  Bioorg. Med. Chem. Lett. (2005) 15(23):5262-5 10.1016/j.bmcl.2005.08.060
• The gem-dialkyl effect in electron transfer reactions: rapid synthesis of seven-membered rings through an electrochemical annulation.
  Sperry JB, Wright DL
  J. Am. Chem. Soc. (2005) 127(22):8034-5 10.1021/ja051826+
• Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action.
  Couch RD, Browning RG, Honda T, Gribble GW, Wright DL, Sporn MB, Anderson AC
  Bioorg. Med. Chem. Lett. (2005) 15(9):2215-9 10.1016/j.bmcl.2005.03.031
• Oxabicyclo[3.2.1]octane derivatives as highly reactive dienophiles: synthesis of bicyclo[5.n.0] systems.
  Pelphrey P, Jasinski J, Butcher RJ, Wright DL
  Org. Lett. (2005) 7(3):423-5 10.1021/ol047725i

• 2004

• Altered specificity of Hint-W123Q supports a role for Hint inhibition by ASW in avian sex determination.
  Parks KP, Seidle H, Wright N, Sperry JB, Bieganowski P, Howitz K, Wright DL, Brenner C
  Physiol. Genomics (2004) 20(1):12-4 (PMC2556054) 10.1152/physiolgenomics.00204.2004
• New chiral building blocks from tetrabromocyclopropene and furan.
  Pelphrey PM, Abboud KA, Wright DL
  J. Org. Chem. (2004) 69(20):6931-3 10.1021/jo048991c
• Electrooxidative coupling of furans and silyl enol ethers: application to the synthesis of annulated furans.
  Sperry JB, Whitehead CR, Ghiviriga I, Walczak RM, Wright DL
  J. Org. Chem. (2004) 69(11):3726-34 10.1021/jo049889i
• A multi-component reaction (MCR) approach to the synthesis of highly diverse polymers with polypeptide-like features.
  Robotham CV, Baker C, Cuevas B, Abboud K, Wright DL
  Mol. Divers. (2004) 6(3-4):237-44
• Bridged synthons from tetrabromocyclopropene: studies on the rearrangement of the primary Diels-Alder adduct with 2,5-dimethylfuran.
  Orugunty RS, Ghiviriga I, Abboud KA, Battiste MA, Wright DL
  J. Org. Chem. (2004) 69(2):570-2 10.1021/jo0352631
• Bicyclo[3.2.1]octane synthons from cyclopropenes: functionalization of cycloadducts by nucleophilic additions.
  Orugunty RS, Wright DL, Battiste MA, Helmich RJ, Abboud K
  J. Org. Chem. (2004) 69(2):406-16 10.1021/jo035240m

• 2002

• Synthesis of functionalized pyrans by domino metathesis reaction of oxabicyclo derivatives: dramatic effect of remote substituents on reactivity and selectivity.
  Usher LC, Estrella-Jimenez M, Ghiviriga I, Wright DL
  Angew. Chem. Int. Ed. Engl. (2002) 41(23):4560-2 10.1002/1521-3773(20021202)41:23<4560::AID-ANIE
• Two-step electrochemical annulation for the assembly of polycyclic systems.
  Whitehead CR, Sessions EH, Ghiviriga I, Wright DL
  Org. Lett. (2002) 4(21):3763-5
• Silver-promoted reactions of bicyclo[3.2.1]octadiene derivatives.
  Orugunty RS, Wright DL, Battiste MA, Abboud KA
  Org. Lett. (2002) 4(12):1997-2000

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