Publications: Charles Giardina

• 2023

• Highly Miniaturized, Low-Power CMOS ASIC Chip for Long-Term Continuous Glucose Monitoring.
  Gudlavalleti RH, Xi X, Legassey A, Chan PY, Li J, Burgess D, Giardina C, Papadimitrakopoulos F, Jain F
  Journal of diabetes science and technology (2023) :19322968231153419 10.1177/19322968231153419
• Incorporation of 53BP1 into phase-separated bodies in cancer cells during aberrant mitosis.
  Bleiler M, Cyr A, Wright DL, Giardina C
  Journal of cell science (2023) 136(1): PMC3664841 10.1126/science.1231573

• 2021

• The Epithelial-Stromal Microenvironment in Early Colonic Neoplasia.
  Ideta T, Li B, Flynn C, Igarashi Y, Lowman G, Looney T, Devers TJ, Birk J, Forouhar F, Giardina C, Rosenberg DW
  Molecular cancer research : MCR (2021) 20(1):56-61 PMC6826139 10.1016/j.cell.2008.03.039
• Fatty acid metabolism and colon cancer protection by dietary methyl donor restriction.
  Aladelokun O, Hanley M, Mu J, Giardina JC, Rosenberg DW, Giardina C
  Metabolomics : Official journal of the Metabolomic Society (2021) 17(9):80 PMC8416812 10.1007/s11306-021-01831-1
• Excitotoxic stimulation activates distinct pathogenic and protective expression signatures in the hippocampus.
  Caba E, Sherman MD, Farizatto KLG, Alcira B, Wang HW, Giardina C, Shin DG, Sandefur CI, Bahr BA
  Journal of cellular and molecular medicine (2021) 25(18):9011-9027 PMC8435451 10.1111/jcmm.16864
• Ferroptosis and its potential as a therapeutic target.
  Yuan H, Pratte J, Giardina C
  Biochemical pharmacology (2021) 186:114486 10.1016/j.bcp.2021.114486

• 2020

• The effect of hyperbaric oxygen on mitochondrial and glycolytic energy metabolism: the caloristasis concept.
  Tezgin D, Giardina C, Perdrizet GA, Hightower LE
  Cell stress & chaperones (2020) 25(4):667-677 PMC7332662 10.1007/s12192-020-01100-5

• 2019

• Inhibition of PGE/EP4 receptor signaling enhances oxaliplatin efficacy in resistant colon cancer cells through modulation of oxidative stress.
  Huang H, Aladelokun O, Ideta T, Giardina C, Ellis LM, Rosenberg DW
  Scientific reports (2019) 9(1):4954 PMC6427013 10.1038/s41598-019-40848-4

• 2018

• Might hyperbaric oxygen therapy (HBOT) reduce renal injury in diabetic people with diabetes mellitus? From preclinical models to human metabolomics.
  Harrison LE, Giardina C, Hightower LE, Anderson C, Perdrizet GA
  Cell Stress Chaperones (2018) 23(6):1143-1152 (PMC6237687) 10.1007/s12192-018-0944-8
• Spindle Assembly Disruption and Cancer Cell Apoptosis with a CLTC-Binding Compound.
  Bond MJ, Bleiler M, Harrison LE, Scocchera EW, Nakanishi M, G-Dayanan N, Keshipeddy S, Rosenberg DW, Wright DL, Giardina C
  Mol. Cancer Res. (2018) 16(9):1361-1372 (PMC6125173) 10.1158/1541-7786.MCR-18-0178

• 2017

• A look into centrosome abnormalities in colon cancer cells, how they arise and how they might be targeted therapeutically.
  Harrison LE, Bleiler M, Giardina C
  Biochem. Pharmacol. (2017) 147:1-8 (PMC5733729) 10.1016/j.bcp.2017.11.003
• A route-based pathway analysis framework integrating mutation information and gene expression data.
  Zhao Y, Hoang TH, Joshi P, Hong SH, Giardina C, Shin DG
  Methods (2017) 124:3-12

• 2016

• Dietary Methyl Donor Depletion Suppresses Intestinal Adenoma Development.
  Hanley MP, Kadaveru K, Perret C, Giardina C, Rosenberg DW
  Cancer Prev Res (Phila) (2016) 9(10):812-820 (PMC5053888)
• Distinct Transcriptional Changes and Epithelial-Stromal Interactions Are Altered in Early-Stage Colon Cancer Development.
  Mo A, Jackson S, Varma K, Carpino A, Giardina C, Devers TJ, Rosenberg DW
  Mol. Cancer Res. (2016) 14(9):795-804 (PMC5025366)
• Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301.
  Chopra A, Bond MJ, Bleiler M, Yeagley M, Wright D, Giardina C
  PLoS ONE (2016) 11(4):e0153818 (PMC4838221)

• 2015

• Regulation of VDR Expression in Apc-Mutant Mice, Human Colon Cancers and Adenomas.
  Giardina C, Nakanishi M, Khan A, Kuratnik A, Xu W, Brenner B, Rosenberg DW
  Cancer Prev Res (Phila) (2015) 8(5):387-99 (PMC4417398)
• Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice.
  Verma R, Chopra A, Giardina C, Sabbisetti V, Smyth JA, Hightower LE, Perdrizet GA
  Cell Stress Chaperones (2015) 20(3):495-505 (PMC4406928)

• 2014

• Therapeutic targeting of the inflammome.
  Wright KT, Giardina C, Vella AT
  Biochem. Pharmacol. (2014) 92(2):184-91 (PMC4722871)
• Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells.
  Ononye SN, Vanheyst MD, Giardina C, Wright DL, Anderson AC
  Bioorg. Med. Chem. (2014) 22(7):2188-93 (PMC4011186)

• 2013

• Development of intestinal organoids as tissue surrogates: cell composition and the epigenetic control of differentiation.
  Cao L, Kuratnik A, Xu W, Gibson JD, Kolling F, Falcone ER, Ammar M, Van Heyst MD, Wright DL, Nelson CE, Giardina C
  Mol. Carcinog. (2013) 54(3):189-202
• Intestinal organoids as tissue surrogates for toxicological and pharmacological studies.
  Kuratnik A, Giardina C
  Biochem. Pharmacol. (2013) 85(12):1721-6
• Quantitation of nucleosome acetylation and other histone posttranslational modifications using microscale NU-ELISA.
  Dai B, Giardina C, Rasmussen TP
  Methods Mol. Biol. (2013) 981:167-76
• Identification of novel compounds that enhance colon cancer cell sensitivity to inflammatory apoptotic ligands.
  Chopra AS, Kuratnik A, Scocchera EW, Wright DL, Giardina C
  Cancer Biol. Ther. (2013) 14(5):436-49 (PMC3672188)

• 2012

• Hyperbaric oxygen preconditioning protects skin from UV-A damage.
  Fuller AM, Giardina C, Hightower LE, Perdrizet GA, Tierney CA
  Cell Stress Chaperones (2012) 18(1):97-107 (PMC3508122)
• Acute sensitization of colon cancer cells to inflammatory cytokines by prophase arrest.
  Kuratnik A, Senapati VE, Verma R, Mellone BG, Vella AT, Giardina C
  Biochem. Pharmacol. (2012) 83(9):1217-28 (PMC3299870)

• 2011

• Vitamin D resistance and colon cancer prevention.
  Giardina C, Madigan JP, Tierney CA, Brenner BM, Rosenberg DW
  Carcinogenesis (2011) 33(3):475-82 (PMC3384070)
• Green tea extract suppresses NFκB activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis.
  Park HJ, Lee JY, Chung MY, Park YK, Bower AM, Koo SI, Giardina C, Bruno RS
  J. Nutr. (2011) 142(1):57-63
• Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells.
  Rigatti MJ, Verma R, Belinsky GS, Rosenberg DW, Giardina C
  Mol. Carcinog. (2011) 51(5):363-78 (PMC3162984)

• 2010

• Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis.
  Montrose DC, Horelik NA, Madigan JP, Stoner GD, Wang LS, Bruno RS, Park HJ, Giardina C, Rosenberg DW
  Carcinogenesis (2010) 32(3):343-50 (PMC3047236)
• Intestinal lineage commitment of embryonic stem cells.
  Cao L, Gibson JD, Miyamoto S, Sail V, Verma R, Rosenberg DW, Nelson CE, Giardina C
  Differentiation (2010) 81(1):1-10
• Hyperbaric oxygen treatment induces antioxidant gene expression.
  Godman CA, Joshi R, Giardina C, Perdrizet G, Hightower LE
  Ann. N. Y. Acad. Sci. (2010) 1197:178-83

• 2009

• Hyperbaric oxygen induces a cytoprotective and angiogenic response in human microvascular endothelial cells.
  Godman CA, Chheda KP, Hightower LE, Perdrizet G, Shin DG, Giardina C
  Cell Stress Chaperones (2009) 15(4):431-42 (PMC3082642)
• DNA damage response to the Mdm2 inhibitor nutlin-3.
  Verma R, Rigatti MJ, Belinsky GS, Godman CA, Giardina C
  Biochem. Pharmacol. (2009) 79(4):565-74 (PMC2794967)
• Mustard gas exposure and carcinogenesis of lung.
  Hosseini-khalili A, Haines DD, Modirian E, Soroush M, Khateri S, Joshi R, Zendehdel K, Ghanei M, Giardina C
  Mutat. Res. (2009) 678(1):1-6 (PMC2811761)

• 2008

• Mouse models for the study of colon carcinogenesis.
  Rosenberg DW, Giardina C, Tanaka T
  Carcinogenesis (2008) 30(2):183-96 (PMC2639048)
• The short chain fatty acid butyrate induces promoter demethylation and reactivation of RARbeta2 in colon cancer cells.
  Spurling CC, Suhl JA, Boucher N, Nelson CE, Rosenberg DW, Giardina C
  Nutr Cancer (2008) 60(5):692-702
• HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling.
  Godman CA, Joshi R, Tierney BR, Greenspan E, Rasmussen TP, Wang HW, Shin DG, Rosenberg DW, Giardina C
  Cancer Biol. Ther. (2008) 7(10):1570-80 (PMC2614677)
• Hsp70B' and Hsp72 form a complex in stressed human colon cells and each contributes to cytoprotection.
  Noonan E, Giardina C, Hightower L
  Exp. Cell Res. (2008) 314(13):2468-76
• Hsp70B' regulation and function.
  Noonan EJ, Place RF, Giardina C, Hightower LE
  Cell Stress Chaperones (2008) 12(4):393-402 (PMC2134801)

• 2007

• Utilizing endoscopic technology to reveal real-time proteomic alterations in response to chemoprevention.
  Nakanishi M, Ménoret A, Belinsky GS, Giardina C, Godman CA, Vella AT, Rosenberg DW
  Proteomics Clin Appl (2007) 1(12):1660-6
• Hsp70B' regulation and function.
  Noonan EJ, Place RF, Giardina C, Hightower LE
  Cell Stress Chaperones (2007) 12(3):219-29 (PMC1971232)
• HDAC3 overexpression and colon cancer cell proliferation and differentiation.
  Spurling CC, Godman CA, Noonan EJ, Rasmussen TP, Rosenberg DW, Giardina C
  Mol. Carcinog. (2007) 47(2):137-47

• 2006

• Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth.
  Belinsky GS, Rajan TV, Saria EA, Giardina C, Rosenberg DW
  Mol. Carcinog. (2006) 46(2):106-16
• Cell number-dependent regulation of Hsp70B' expression: evidence of an extracellular regulator.
  Noonan EJ, Place RF, Rasoulpour RJ, Giardina C, Hightower LE
  J. Cell. Physiol. (2006) 210(1):201-11
• Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer.
  Stevens RG, Swede H, Heinen CD, Jablonski M, Grupka M, Ross B, Parente M, Tirnauer JS, Giardina C, Rajan TV, Rosenberg DW, Levine J
  Cancer Lett. (2006) 248(2):262-8
• Circumvention and reactivation of the p53 oncogene checkpoint in mouse colon tumors.
  Aizu W, Belinsky GS, Flynn C, Noonan EJ, Boes CC, Godman CA, Doshi B, Nambiar PR, Rosenberg DW, Giardina C
  Biochem. Pharmacol. (2006) 72(8):981-91

• 2005

• HDACs and the senescent phenotype of WI-38 cells.
  Place RF, Noonan EJ, Giardina C
  BMC Cell Biol. (2005) 6:37 (PMC1285358)
• HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity: down-regulation of proteasome subunit expression stabilizes I kappa B alpha.
  Place RF, Noonan EJ, Giardina C
  Biochem. Pharmacol. (2005) 70(3):394-406
• Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis.
  Dong M, Johnson M, Rezaie A, Ilsley JN, Nakanishi M, Sanders MM, Forouhar F, Levine J, Montrose DC, Giardina C, Rosenberg DW
  Clin. Cancer Res. (2005) 11(6):2265-71
• Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors.
  Tong X, Yin L, Joshi S, Rosenberg DW, Giardina C
  J. Biol. Chem. (2005) 280(16):15503-9

• 2004

• The p50-p50 NF-kappaB complex as a stimulus-specific repressor of gene activation.
  Tong X, Yin L, Washington R, Rosenberg DW, Giardina C
  Mol. Cell. Biochem. (2004) 265(1-2):171-83
• Azoxymethane-induced pre-adipocyte factor 1 (Pref-1) functions as a differentiation inhibitor in colonic epithelial cells.
  Dong M, Guda K, Nambiar PR, Nakanishi M, Lichtler AC, Nishikawa M, Giardina C, Rosenberg DW
  Carcinogenesis (2004) 25(11):2239-46
• Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition.
  Tong X, Yin L, Giardina C
  Biochem. Biophys. Res. Commun. (2004) 317(2):463-71
• Silica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity.
  Thibodeau MS, Giardina C, Knecht DA, Helble J, Hubbard AK
  Toxicol. Sci. (2004) 80(1):34-48

• 2003

• p53 and its co-activator p300 are inversely regulated in the mouse colon in response to carcinogen.
  Aizu W, Guda K, Nambiar P, Xin T, Thibodeau M, Rosenberg DW, Giardina C
  Toxicol. Lett. (2003) 144(2):213-24
• Silica-induced caspase activation in mouse alveolar macrophages is dependent upon mitochondrial integrity and aspartic proteolysis.
  Thibodeau M, Giardina C, Hubbard AK
  Toxicol. Sci. (2003) 76(1):91-101
• Induced stabilization of IkappaBalpha can facilitate its re-synthesis and prevent sequential degradation.
  Place RF, Haspeslagh D, Giardina C
  J. Cell. Physiol. (2003) 195(3):470-8
• Interspecific hybridization induced amplification of Mdm2 on double minutes in a Mus hybrid.
  Brown JD, Strbuncelj M, Giardina C, O'Neill RJ
  Cytogenet. Genome Res. (2003) 98(2-3):184-8
• Inverse association between phospholipase A2 and COX-2 expression during mouse colon tumorigenesis.
  Dong M, Guda K, Nambiar PR, Rezaie A, Belinsky GS, Lambeau G, Giardina C, Rosenberg DW
  Carcinogenesis (2003) 24(2):307-15

• 2002

• Growing old with nuclear factor-kappaB.
  Giardina C, Hubbard AK
  Cell Stress Chaperones (2002) 7(2):207-12 (PMC514819)
• Role of the alternating reading frame (P19)-p53 pathway in an in vivo murine colon tumor model.
  Nambiar PR, Giardina C, Guda K, Aizu W, Raja R, Rosenberg DW
  Cancer Res. (2002) 62(13):3667-74

• 2001

• Butyrate suppression of colonocyte NF-kappa B activation and cellular proteasome activity.
  Yin L, Laevsky G, Giardina C
  J. Biol. Chem. (2001) 276(48):44641-6
• Cellular and molecular mechanisms regulating silica-induced adhesion molecule expression in mice.
  Hubbard AK, Thibodeau M, Giardina C
  J. Environ. Pathol. Toxicol. Oncol. (2001) 20 Suppl 1:45-51
• Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors.
  Guda K, Giardina C, Nambiar P, Cui H, Rosenberg DW
  Mol. Carcinog. (2001) 31(4):204-13
• Cytokine-induced stabilization of newly synthesized I(kappa)B-alpha.
  Place RF, Haspeslagh D, Hubbard AK, Giardina C
  Biochem. Biophys. Res. Commun. (2001) 283(4):813-20

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